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Effect of ECM composition on swelling stress. (A) Representative immunofluorescence staining sections for hyaluronan (HA) and collagen (scale bar 100 μm), (B) Swelling stress as a function of HA area fraction, and (C) collagen area fraction showing no correlation. (D) Swelling stress is linearly proportional to the ratio of HA/collagen area fraction (y = 4.089x − 2.057, R2 = 0.825). Five tumor specimens (n = 5) from each tumor type were used.
