Table 1.

GIV is essential for a variety of physiologic cellular processes.

Cellular Processes	Effect of GIV's GEF function	Receptor(s) studied	Citation
Cell Migration	“ON” = Enhances; “OFF” = Inhibits	EGFR, PDGFR, VEGFR, IGF1R, LPAR1	[2–5,8–10,44]
Golgi Structure, Secretory Function	“ON” = Preserves/enhances; “OFF” = Disrupts, delays	n/a	[70]
Autophagy	“ON” = Halt/rescue; “OFF” = Initiate/promote	InsR	[6]
Endosome Maturation	“ON” = Rapid; “OFF” = Slowed	EGFR	[87]
Cell Survival	“ON” = Survive; “OFF” = Apoptosis	PDGFR, VEGFR, EGFR	[4,11]
Cell polarity***	“ON” = Polarity achieved; “OFF” = Loss of polarity	Serum (multiple receptors)	[18,88]
Cell Division	Not examined	n/a	[89]
Endocytosis	Not examined	EGFR, TfR	[90]
Cell-cell junctions, permeability***	Not examined	VEGFR	[91]
Neuron migration, differentiation***	Not examined	n/a	[92,93]
Macrophage chemotaxis	Not examined	fMLPR	[8]
Growth, Cell Size***	Not examined	n/a	[94]

^***= In vivo evidence is available.