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Melting temperature values of serine β-lactamases and their respective serine nucleophile mutants.
| β-Lactamase | Tm (°C) | ΔTm (°C) |
|---|---|---|
| TEM-1 | 54.2 | - |
| TEM-1 S70G | 56.3 | 2.1 |
| TEM-1 S70A | 54.6 | 0.4 |
| CTX-M-14 | 58.2 | - |
| CTX-M-14 S70G | 62.2 | 4.0 |
| KPC-2 | 63.3 | - |
| KPC-2 S70G | 76.6 | 13.3 |
| P99 | 61.9 | - |
| P99 S64G | 71.5 | 9.6 |
| OXA-48 | 58.9 | - |
| OXA-48 S70G | 63.5 | 4.6 |
| OXA-48 S70A | 59.5 | 0.6 |
| OXA-163 | 55.2 | - |
| OXA-163 S70G | 58.6 | 3.4 |
| OXA-163 S70A | 55 | −0.2 |
