Table 3.
Patient and treatment characteristics in series of patients with tumors involving kidneys with fusion anomalies
| Series | Kidney Anomaly |
Presenting Symptoms |
Operation Type |
Median Operative Time (min) |
Patients With Vascular Anomalies |
Estimated Blood Loss (mL) |
Tumor Pathology | Patients With Postoperative Complications |
Functional Outcome |
Survival Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| Rubio Briones et al4 | 10 HK | 9 local (90%); 1 incidental (10%) | 8 RN (80%); 2 NU (20%) | NA | 7 (70%) | 2195 (mean); 500–7000 (range) | 5 RCC (50%); 4 UC (40%); 1 Wilms’ tumor (10%) | NA | Patients alive at follow-up have normal renal function | Median FU—36.5 months, CSS—70%, OS—60% |
| Stimac et al6 | 4 HK; 1 CFE | 5 local (100%) | 3 RN (60%); 1 NU (20%); 1 PN (20%) | NA | NA | NA | 2 RCC (40%); 2 UC (40%); 1 oncocytoma (20%) | NA | Patients alive at follow-up have normal renal function | Median FU—12 months, CSS and OS—80% |
| Yecies et al10 | 8 HK | NA | 8 RN or PN* | 102 (IQR, 92–357) | NA | NA; 2 patients (25%) required blood transfusion | 7 RCC (88%); 1 carcinoid tumor (12%) | 1 overall (13%), 1 major (13%) | Median change in eGFR −6 mL/min/1.73 m2, none required renal replacement† | Median FU—38.5 months, CSS—87.5%, OS—62.5% |
| Current series | 7 HK; 2 CFE | 3 local (33%); 6 incidental (67%) | 7 PN (78%); 2 NU (22%) | 157 (IQR, 144–267) for PN; 229 (range 40–417) for NU | 8 (89%) | 400 (IQR, 200–1500) for PN; 200 (range 100–300) for NU | 5 RCC (56%); 2 UC (22%); 1 oncocytoma (11%); 1 liposarcoma (11%) | 3 overall (43%), 2 major (29%) for PN; 1 overall (50%), 0 major for NU | Median change in eGFR −7 mL/min/1.73 m2 for PN and −15.1 mL/min/1.73 m2 for NU; no new onset of CKD | Median FU—19.2 months CSS—100%, OS—89% |
CKD, chronic kidney disease; CSS, cancer-specific survival; eGFR, estimated glomerular filtration rate; FU, follow-up; IQR, interquartile range; OS, overall survival; RN, radical nephrectomy. Categorical variables are presented as number and percent, and continuous variables as median and interquartile range or mean and standard deviation
All patients underwent either partial nephrectomy or heminephrectomy. Exact number of patients undergoing each type of procedure was not mentioned.
There were 3 of 7 patients (43%) who had a preoperative eGFR > 60 mL/min/1.73 m2 that had a decline in eGFR at discharge to less than 60 mL/min/1.73 m2.