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. Author manuscript; available in PMC: 2017 Nov 17.
Published in final edited form as: Cell. 2016 Nov 17;167(5):1188–1200. doi: 10.1016/j.cell.2016.10.024

Figure 2. Insulated neighborhoods.

Figure 2

A. Hierarchy of chromosome structures: Chromosome territories, Topologically Associating Domains and insulated neighborhoods. Anchor refers to the CTCF-bound site interacting with another CTCF-bound sites, both co—bound by a cohesin ring.

B. Features of insulated neighborhoods in human embryonic stem cells (ESCs). The values displayed for the size range and number of genes represent the middle 95% of the data range.

C. Evidence for insulation of insulated neighborhoods: 97% Enhancer-gene interactions occur within insulated neighborhoods in human ESCs.

D. Evidence for insulation of insulated neighborhoods: Deletion of insulated neighborhood anchors leads to gene misregulation.

E. Evidence for insulation of insulated neighborhoods: Mutations of insulated neighborhood anchors in tumor cells leads to oncogene activation.