Dear editor
I read with interest the article by Brawer and Goel in the August 2016 issue of journal Open Access Rheumatology: Research and Reviews on the onset of rheumatoid arthritis following trauma.1 However, I was troubled by the lack of transparency in, at least, the lead author’s case regarding conflict of interest. They acknowledged that the relationship between trauma and rheumatoid arthritis is the “subject of considerable controversy.” However, the lead author has given medical legal expert testimony arguing for such a relationship. A third of the subjects were attorney referred, and presumably involved in cause and effect litigation, and the incidence of litigation in the other 40 subjects is not reported. The inherent bias needs to be revealed to the reader.
Conflict of interest is defined as “prejudice or bias that may occur when one’s impartiality is compromised by opportunities for personal gain or occupational advancement, or by the chance that one’s work may support a favored point of view or social agenda.”2 Conflict of interest has become a very important topic in medicine to guard against bias, usually from industry, that is, pharmaceutical and device manufacturers. There is a substantial amount of literature indicating that studies and their outcomes can be influenced by conflicts of interest.3 In 2009, Blum et al reported that only 42% of medical journals included paid expert testimony as part of their conflict of interest policy.4 Open Access Rheumatology: Research and Reviews requests, in an open ended fashion, that all possible conflicts of interest be declared.
Medical expert testimony is usually not a part of traditional drug and device studies. However, because the study by Brawer and Goel very directly addresses the lead author’s bias in his expert witness testimony from which there is generally direct monetary gain, it behooves him to report such a conflict of interest so that the reader can determine the validity of data by himself or herself. No one is invulnerable to such monetary influences.5
Footnotes
Disclosure
The author supplies medical expert opinion and testimony in cases involving juvenile idiopathic arthritis and trauma. The author reports no other conflicts of interest in this communication.
References
- 1.Brawer AE, Goel N. The onset of rheumatoid arthritis following trauma. Open Access Rheumatol Res Rev. 2016;8:77–80. doi: 10.2147/OARRR.S110560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Farlex Medical Dictionary. 2009. [Accessed September 18, 2016]. Available from: http://medical-dictionary.thefreedictionary.com/conflict+of+interest.
- 3.Lo B, Field MJ, editors. Conflict of Interest in Medical Research, Education, and Practice. Washington, DC: National Academies Press; 2009. [PubMed] [Google Scholar]
- 4.Blum JA, Freeman K, Dart RC, Cooper RJ. Requirements and definitions in conflict of interest policies of medical journals. JAMA. 2009;302(20):2230–2234. doi: 10.1001/jama.2009.1669. [DOI] [PubMed] [Google Scholar]
- 5.Sah S. Conflicts of interest and your physician: psychological processes that cause unexpected changes in behavior. J Law Med Ethics. 2012;40(3):482–487. doi: 10.1111/j.1748-720X.2012.00680.x. [DOI] [PubMed] [Google Scholar]