Table 3.
Significant (p<0.005) differentially expressed lncRNA probesets and those that changed over time in male and female whole blood samples and proximity to putative ischemic stroke or vascular risk factor-related genes and/or SNPs. (Fold Change (FC)>1.2=increased expression level in IS vs VRFC). (Partial correlation r < −0.4=decreasing expression over time).
| Probeset, lncRNA ID | Sex | Cyto-band | Gene/SNP in Region | lncRNA up-/down-stream | lncRNA Distance (kb) from Gene / SNP | FC or r Values | Ref |
|---|---|---|---|---|---|---|---|
| PSR06037329, linc-SLC22A2 | M | 6p25.3 | LPAL2 SLC22A3 LPA rs10455872 |
within up down down |
within 14.0 146.2 69.2 |
FC=1.36 | 48 |
| PSR09027609, linc-OBP2B-1 | M | 9q34.2 | ABO rs579459 |
down down |
44.3 48.1 |
FC=1.42 | 48 |
| PSR20015349, OTTHUMT-00000079682 | F | 20q13.13 | PTGIS | up | 132.7 | FC=1.41 | 50 |
| PSR04025299, linc_luo_1172 | F | 4p16.3 | ADD1 | down | 332.6 | FC=1.22 | 51, 52 |
| PSR19028831, ENST00000507442 | M | 19q13.32 | APOE | down | 219.6 | r = −0.49 | 54 |
| APOC1 | down | 209.7 | |||||
| rs445925 | down | 216.4 | |||||
| PSR20017082, ENST0000079667 | M | 20q13.13 | PTGIS | up | 28.96 | r = −0.40 | 55 |
| PSR04029574, NR_036641 | F | 4q32.1 | PDGFC | within | within | r = −0.41 | 53 |