Table 3.
Multivariable-adjusted associations of serum albumin and AST with all-cause mortality
| Parameter | Overall (n=913) Odds of mortality (95% CI) |
HCV+/HIV+ (n=193) Odds of mortality (95% CI) |
HIV Monoinfected (n=720) Odds of mortality (95% CI) |
Test for HCV × factor interaction P-value |
|---|---|---|---|---|
| Serum Albumin (per 0.5 g/dL decrease) |
1.49 (1.17, 1.89) p=0.0010 |
2.1 (1.39, 3.2) p=0.0005 |
1.28 (0.98, 1.69) p=0.074 |
0.038 |
| AST (doubling) |
1.41 (1.09, 1.81) p=0.0076 |
2.5 (1.54, 4.1) p=0.0002 |
1.08 (0.77, 1.51) p=0.67 |
0.0042 |
| Current vs. Never Smoker | 3.2 (1.83, 5.5) p<.0001 |
2.5 (1.01, 6.1) p=0.046 |
3.5 (1.89, 6.6) p<.0001 |
0.46 |
| Past vs. Never Smoker | 1.68 (0.88, 3.2) p=0.12 |
1.86 (0.57, 6.1) p=0.30 |
1.64 (0.82, 3.3) p=0.16 |
0.75 |
| Arm SM Tertile 2 vs. Tertile 1 | 0.59 (0.35, 0.99) p=0.046 |
0.62 (0.25, 1.57) p=0.31 |
0.57 (0.31, 1.06) p=0.077 |
0.42 |
| Arm SM Tertile 3 vs. Tertile 1 | 0.48 (0.23, 1.00) p=0.050 |
0.53 (0.19, 1.43) p=0.21 |
0.46 (0.18, 1.15) p=0.093 |
0.70 |
| VAT Tertile 2 vs. Tertile 1 | 2.2 (1.21, 3.8) p=0.0095 |
2.3 (0.90, 5.6) p=0.082 |
2.1 (1.13, 4.0) p=0.019 |
0.69 |
| VAT Tertile 3 vs. Tertile 1 | 2.7 (1.41, 5.1) p=0.0027 |
3.5 (1.31, 9.2) p=0.013 |
2.4 (1.17, 5.0) p=0.017 |
0.36 |
| Leg SM Tertile 2 vs. Tertile 1 | 0.95 (0.55, 1.61) p=0.84 |
0.91 (0.39, 2.1) p=0.83 |
0.97 (0.53, 1.78) p=0.91 |
0.97 |
| Leg SM Tertile 3 vs. Tertile 1 | 0.44 (0.22, 0.90) p=0.025 |
0.51 (0.17, 1.52) p=0.23 |
0.41 (0.19, 0.91) p=0.029 |
0.83 |
| CD4 (per doubling) | 0.63 (0.55, 0.72) p<.0001 |
0.86 (0.67, 1.09) p=0.21 |
0.56 (0.48, 0.66) p<.0001 |
0.0049 |
| Non HDLc (per 10 mg/dL) | 0.94 (0.90, 0.98) p=0.0031 |
0.91 (0.81, 1.01) p=0.074 |
0.94 (0.90, 0.99) p=0.0099 |
0.54 |
| Amprenavir (total duration) | 2.1 (1.31, 3.5) p=0.0022 |
2.3 (0.099, 53.1) p=0.60 |
2.1 (1.30, 3.5) p=0.0026 |
0.96 |
| CRP (doubling) | 1.19 (1.04, 1.35) p=0.0095 |
1.32 (1.07, 1.61) p=0.0081 |
1.10 (0.94, 1.29) p=0.23 |
0.16 |
| Fibrinogen (doubling) | 2.1 (1.17, 3.8) p=0.013 |
1.31 (0.47, 3.6) p=0.60 |
2.5 (1.28, 4.8) p=0.0072 |
0.27 |
| eGFRcys (per 10 ml/min/1.73m2) | 0.90 (0.81, 1.00) p=0.041 |
0.89 (0.74, 1.06) p=0.19 |
0.90 (0.79, 1.02) p=0.089 |
0.92 |
Note: Multivariable-adjusted models control for age, gender, race/ethnicity, serum albumin, AST, smoking, arm SM, VAT, Leg SM, CD4 count, non-HDLc, amprenavir, CRP, Fibrinogen, and eGFRcys.
Abbreviations: CI, confidence interval; SM, skeletal muscle; VAT, visceral adipose tissue; CRP, C-reactive protein