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(A–B) Dose-response analysis of YUKA1 (A) and YUKA2 (B) over a 16-fold range of concentrations of α-KG. (C–D) Inhibition of KDM5A by YUKA1 (C) and YUKA2 (D) in reactions with varying concentrations of Fe(II). (E–F) Dose-response analysis of YUKA1 (E) and YUKA2 (F) at the indicated Fe(II) concentrations. Data points in A-F indicate mean ± SEM. Data are representative of at least two independent experiments performed in triplicate.
