Table 1. Chromosome of Adipocytes specific miRNAs distribution compared with obese gene map.
| miRNA Name | Localization | Population | Phenotypes |
|---|---|---|---|
| hsa-miR-34a | 1p36.22 | >168 pairs | Skinfolds, uprailiac |
| hsa-miR-128-1 | 2q21.3 | 453 subjects, 99 families | Abdominal visceral fat |
| hsa-miR-26b | 2q35 | 453 subjects, 99 families | Abdominal visceral fat |
| hsa-miR-128-2 | 3p22.3 | 377 pairs | Body fat (%) |
| hsa-miR-26a-1 | 3p22.2 | 580 families | BMI |
| hsa-miR-143 | 5q32 | 453 subjects, 99 families | Abdominal total fat |
| hsa-miR-145 | 5q32 | 453 subjects, 99 families | Abdominal total fat |
| hsa-miR-378 | 5q32 | 453 subjects, 99 families | Abdominal total fat |
| hsa-miR-25 | 7q22.1 | 261 subjects, 27 pedigrees, 1297 subjects, 260 families | High-density lipoprotein, in triglyceridesBMI |
| hsa-miR-93 | |||
| hsa-miR-106b | |||
| hsa-miR-335 | 7q32.2 | 545 pairs | BMI |
| hsa-miR-29a | 7q32.3 | 3027 subjects, 401 families, 317 sibships | BMI |
| hsa-miR-320a | 8p21.3 | 994 subjects, 37 pedigrees | BMI |
| hsa-miR-1915 | 10p12.31 | 667 subjects, 244 families; 862 subjects, 170 families |
Obesity (in whites and African Americans) Obesity (inAfrican Americans, in European Americans) |
| hsa-miR-605 | 10q21.1 | 672 subjects, 28 pedigrees; 862 subjects, 170 families |
Leptin, Obesity |
| hsa-miR-146b | 10q24.32 | 447 subjects, 109 pedigrees | BMI > 27 |
| hsa-miR-130a | 11q12.1 | 369 subjects, 89 families | Obesity (in white children and adolescents) |
| hsa-miR-125b-1 | 11q24.1 | 430 subjects, 27 sibpairs, 27 pedigrees;1526 pairs;1778 sibships;994 subjects, 37 pedigrees | BMI |
| hsa-let-7a-2 | |||
| hsa-miR-100 | |||
| hsa-miR-196a-2 | 12q13.13 | 729 subjects, 275 families | Waist-to-hip ratio |
| hsa-miR-26a-2 | 12q14.1 | 514 subjects, 99 families, 347 sibships | Fat intake |
| hsa-let-7i | |||
| hsa-miR-16-1 | 13q14.2 | 3027 subjects, 401 families, 317 sibships | BMI |
| hsa-miR-17 | 13q31.3 | 1297 subjects, 260 families; 1297 subjects, 260 families; 1312 subjects, 696 families | BMI, paternal, Waist circumference, paternal; BMI; Factor central obesity |
| hsa-miR-18a | |||
| hsa-miR-20a | |||
| hsa-miR-19b-1 | |||
| hsa-miR-92a-1 | |||
| hsa-miR-1260 | 14q24.3 | 672 subjects, 28 pedigrees | Leptin |
| hsa-miR-1469 | 15q26.2 | 336 sibpairs, 609 relative pairs | Fat-free mass |
| hsa-miR-365-1 | 16p13.12 | 893 sibpairs | BMI (in whites) |
| hsa-miR-22 | 17p13.3 | 729 subjects, 275 families | Abdominal subcutaneous fat |
| hsa-miR-132 | 17p13.3 | ||
| hsa-miR-195 | 17p13.1 | 478 subjects, 10 families | asp levels |
| hsa-miR-423 | 17q11.2 | 470 subjects, 10 families | BMI |
| hsa-miR-365-2 | 17q11.2 | ||
| hsa-miR-152 | 17q21.32 | 521 subjects, 156 families | Abdominal subcutaneous fat |
| hsa-miR-196a-1 | 17q21.32 | ||
| hsa-miR-638 | 19p13.2 | 522 subjects, 99 families, 364 sibpairs | Skinfolds, sum of eight (in whites), Leptin (in whites), Body fat (%) (in whites) |
| hsa-miR-199a-1-5p | 19p13.2 | ||
| hsa-miR-199a-1-3p | 19p13.2 | ||
| hsa-miR-24-2 | 19p13.13 | 506 subjects, 115 pedigrees | Age adiposity rebound |
| hsa-miR-27a | 19p13.13 | ||
| hsa-miR-23a | 19p13.13 | ||
| hsa-miR-155 | 21q21.3 | 1510 subjects, 509 families | Factor central obesity |
| hsa-let-7a-3 | 22q13.31 | >168 pairs | Body weight |
| hsa-let-7b | 22q13.31 | ||
| hsa-miR-221 | Xp11.3 | 1148 subjects, 133 families, 190 European-American families (940 members), 43 African-American families (208 members) | Waist-to-hip ratio (in European Americans and African Americans) |
| hsa-miR-222 |
Note: The Human Obesity Gene Map: The 2005 Update