Table 2. Biological characteristics of three main CDK11 isoforms.

CDK11 isoforms	Molecular Weight	Cyclin Partners	Subcellular Localization	Cell Cycle Expression	Expression in Cancer	Cellular Functions
CDK11p110	110 kDa	cyclins L1 and L2	nucleus	throughout cell cycle	highly expressed	transcription RNA splicing hedgehog signaling pathway Wnt/β-catenin signaling pathway
CDK11p58	58 kDa	cyclins L1, L2 and D3	nucleus and cytoplasm	transiently in G2/M phase	unknown	mitosis process centrosome maturation bipolar spindle assembly
CDK11p46	46 kDa	cyclins L1 and L2	cytoplasm	transiently	unknown	apoptosis autophagy