We examined 26 different mouse models related to autism and identified three groups that shared similar neuroanatomical phenotypes. These three groups and their regional differences are shown here. Anything highlighted in red was determined to be larger in that group (median effect size for group >0.5) and anything highlighted in blue was determined to be smaller in that group (median effect size for group < − 0.5). These differences are shown in 3D in an axial representation either looking from above (a) or below (b) the mouse brain. For more information on this topic, please refer to the article by Ellegood et al on pages 118–125.
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Psychiatry. 2015 Feb;20(1):1. doi: 10.1038/mp.2014.168
3D visualization of the regional differences
J Ellegood
1, E Anagnostou
2, BA Babineau
3, JN Crawley
3,4, L Lin
5, M Genestine
5, E DiCicco-Bloom
5, JKY Lai
6, JA Foster
6, O Peñagarikano
7, DH Geschwind
7, LK Pacey
8, DR Hampson
8, CL Laliberté
1, AA Mills
9, E Tam
10, LR Osborne
10, M Kouser
11, F Espinosa-Becerra
11, Z Xuan
11, CM Powell
11, A Raznahan
12, DM Robins
13, N Nakai
14, J Nakatani
14, T Takumi
14, MC van Eede
1, TM Kerr
15, C Muller
15, RD Blakely
15, J Veenstra-VanderWeele
15, RM Henkelman
1,16, JP Lerch
1,16
J Ellegood
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
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E Anagnostou
2Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
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JN Crawley
3National Institute of Mental Health, Bethesda, MD, USA
4MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA
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M Genestine
5UMDNJ - Robert Wood Johnson Medical School, Piscataway, NJ, USA
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E DiCicco-Bloom
5UMDNJ - Robert Wood Johnson Medical School, Piscataway, NJ, USA
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JKY Lai
6The Brain-Body Institute, McMaster University, Hamilton, Ontario, Canada
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JA Foster
6The Brain-Body Institute, McMaster University, Hamilton, Ontario, Canada
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O Peñagarikano
7Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
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DH Geschwind
7Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
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LK Pacey
8Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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DR Hampson
8Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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CL Laliberté
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
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E Tam
10Departments of Medicine and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
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LR Osborne
10Departments of Medicine and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
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M Kouser
11University of Texas Southwestern Medical Center, Dallas, TX, USA
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F Espinosa-Becerra
11University of Texas Southwestern Medical Center, Dallas, TX, USA
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CM Powell
11University of Texas Southwestern Medical Center, Dallas, TX, USA
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DM Robins
13Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA
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MC van Eede
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
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TM Kerr
15Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Nashville, TN, USA
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C Muller
15Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Nashville, TN, USA
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RD Blakely
15Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Nashville, TN, USA
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J Veenstra-VanderWeele
15Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Nashville, TN, USA
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RM Henkelman
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
16Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
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JP Lerch
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
16Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
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1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
2Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
3National Institute of Mental Health, Bethesda, MD, USA
4MIND Institute, University of California Davis School of Medicine, Sacramento, CA, USA
5UMDNJ - Robert Wood Johnson Medical School, Piscataway, NJ, USA
6The Brain-Body Institute, McMaster University, Hamilton, Ontario, Canada
7Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
8Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
9Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
10Departments of Medicine and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
11University of Texas Southwestern Medical Center, Dallas, TX, USA
12National Institutes of Health, Bethesda, MD, USA
13Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA
14RIKEN Brain Science Institute, Wako, Japan
15Vanderbilt Kennedy Center, Vanderbilt Brain Institute, Nashville, TN, USA
16Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
PMCID: PMC5131793 NIHMSID: NIHMS826931 PMID: 25648202
The publisher's version of this article is available at Mol Psychiatry