Table 4.
Association between preoperative concentrations of branched chain amino acids, aromatic amino acids, and short-chain fatty acids and BMI *.
| Mean Serum Metabolite Concentrations by BMI Quartile | Pearson’s Correlation | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Overall n = 30 |
35–44 n = 7 |
45–54 n = 10 |
55–64 n = 7 |
65+ n = 6 |
p-value1 | p-value2 | r | p-value | |
| Leucine, µmol/L | 129.8 (24.3) | 117.2 (25.1) | 141.2 (27.4) | 131.7 (17.1) | 123.4 (20.9) | 0.824 | 0.828 | 0.008 | 0.965 |
| Isoleucine, µmol/L | 61.7 (14.5) | 58.1 (14.8) | 66.7 (18.9) | 63.3 (7.2) | 55.7 (11.5) | 0.677 | 0.678 | –0.125 | 0.511 |
| Valine, µmol/L | 247.6 (45.2) | 226.2 (56.1) | 265.8 (44.1) | 241.4 (25.3) | 249.3 (49.4) | 0.570 | 0.573 | 0.073 | 0.700 |
| Phenylalanine, µmol/L | 83.3 (15.9) | 71.1 (4.6) | 90.3 (19.2) | 82.4 (17.9) | 86.9 (7.7) | 0.137 | 0.145 | 0.257 | 0.171 |
| Tyrosine, µmol/L | 66.2 (19.2) | 64.0 (19.7) | 75.5 (23.1) | 54.9 (10.0) | 66.5 (15.6) | 0.692 | 0.692 | –0.107 | 0.575 |
| Butyric Acid, µmol/L | 0.55 (0.21) | 0.46 (0.10) | 0.50 (0.24) | 0.53 (0.13) | 0.74 (0.23) | 0.016 | 0.018 | 0.446 | 0.013 |
| Isovaleric Acid, µmol/L | 0.34 (0.24) | 0.35 (0.22) | 0.27 (0.11) | 0.24 (0.10) | 0.56 (0.41) | 0.136 | 0.142 | 0.252 | 0.179 |
| Valeric Acid, µmol/L | 0.34 (0.13) | 0.27 (0.07) | 0.30 (0.12) | 0.39 (0.16) | 0.42 (0.12) | 0.014 | 0.012 | 0.439 | 0.015 |
| Isocaproic Acid, µmol/L | 0.04 (0.04) | 0.04 (0.03) | 0.03 (0.02) | 0.03 (0.02) | 0.07 (0.06) | 0.124 | 0.119 | 0.364 | 0.048 |
| Hexanoic Acid, µmol/L | 0.87 (0.34) | 0.69 (0.15) | 0.83 (0.26) | 0.99 (0.57) | 1.00 (0.22) | 0.073 | 0.072 | 0.292 | 0.118 |
Data presented as mean (standard deviation). p-value1 = linear trend without adjustment. p-value2 = linear trend with adjustment for diabetes. * Serum samples were available for 30 patients for the above analyses.