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. Author manuscript; available in PMC: 2016 Dec 2.
Published in final edited form as: Biomaterials. 2015 Dec 2;81:27–35. doi: 10.1016/j.biomaterials.2015.11.063

Fig. 5.

Fig. 5

Cell nuclei orientation and aspect ratio were found for all fiber geometries and dimensions as indication of cell migration and alignment along the length of the channel. (A) Nuclei were fit with an ellipse to find the major (l) and minor (w) diameters to calculate nuclear aspect ratio as well as the angle between the major axis and the angle of the channel. (B) Cell nuclei were more aligned along the length of the channel for narrower round and square fibers (50 μm compared to 200 μm), but demonstrated a high degree of alignment for all dimensions of grooved NGCs. (C) A higher nuclear aspect ratio was observed for narrower round and square channels as well as all grooved NGCs. All values are mean ± S.D. *Statistically significant (p<0.05) (one-way ANOVA)