Table 4.

Key protocol details for Cambridge MRC-Hip Fx study (LREC 99/076).

Protocol title, REC number, REC committee	Measurement of femoral neck bone loss in cases of hip fracture compared to hospital controls MRC LREC99/076 version 1.0. Cambridge Research Ethics Committee
Objective	To estimate cortical bone stability in the contralateral hip of fracture cases compared with measurements of age matched controls
Study design	Case Control study, convenience sampling for cases and controls
Setting	Single centre, Cambridge, UK. Recruitment started in 2001
Participants	Eligibility - inclusion criteria. Cases Female with first hip fracture (femoral neck or trochanteric) post surgical fixation, able to understand, ask questions and give witnessed consent, medically stabilised. Controls healthy volunteers attending Addenbrooke's NHS Trust for a routine clinical CT scan which includes the abdomen and pelvis, who were subsequently found to have no carcinoma. Exclusion criteria- Dementia/cognitive impairment, unconsciousness, terminal illness, metastatic cancer, previous hip replacement (synthetic material at either hip), previous hip fracture, osteomyelitis, bone tumour, known history of metabolic bone disease, those taking oral corticosteroids, women already enrolled in a study involving x-rays.
Participants used for present analysis (n)	Study 1.2 and 1.3 healthy controls 18
Scan protocol	See FEMCO study. Not using GE Lightspeed scanner
Bone density analysis	aBMD of the femoral neck and total hip region region using traditional ROIs specified in CTXA software (QCTpro v 5.1.3)