Table 5.

Key protocol details for Prague Study of Hip Joint in Trauma study.

Protocol title, REC number, REC committee	Study of Hip Joint in Trauma IRB0002384101 (Ethical Committee of the Institute of Rheumatology and Ethical Committee of Bulovka Hospital). FEMCO amendment (approved by Cambridgeshire LREC4)
Objective	To measure bone density by QCT in the femoral head of fracture cases compared with age matched controls.
Study design	Case Control study, convenience sampling for cases and controls
Setting	Single centre, Prague, Czech Republic. Recruitment started in 2006
Participants	Eligibility- inclusion criteria. Cases Female with first hip fracture (femoral neck or trochanteric) attending Bulovka University Hospital Prague, awaiting surgical fixation, able to give informed consent, low energy injury. Controls healthy volunteers by invitation at rheumatology clinics and two residential care centres in the same districts of Prague, attending Homolka Hospital Prague. Exclusion criteria- terminal illness, metastatic cancer, previous hip replacement (synthetic material at either hip), subtrochanteric fracture, known history of unilateral bone disease.
Participants used for present analysis (n)	Study 1.2 Hip fracture cases 78 (40 femoral neck 38 trochanteric) Study 1.2 Control fallers 75
Scan protocol	Patient Positioning for Hip QCT Supine on Siemens Somatom Sensation 16 or 40 scanner. Siemens two-compartment Osteo phantom. Reconstruction: To capture both hips and the phantom in each reconstruction. Siemens B10/B20s convolution kernel, ≤ 1 mm reconstructed slice thickness CT DICOM format images. Fracture classification: A consultant radiologist (TDT) reconstructed CT images with a multiplanar reformat (MPR) and classified the fracture as subcapital, transcervical or trochanteric using the Muller AO classification, based on the anterior extent of the fracture line. Image Processing: QCT PRO CTXA software (v5.1.3)- Reconstruct 3D image, analyse each hip for vBMD, aBMD. Segmentation of contralateral hip in fracture patients (Stradwin v 4.0) or both hips in control patients followed by Bone Mapping. Further details in journal article [6]
Bone density analysis	aBMD of the femoral neck and total hip region region using traditional ROIs specified in CTXA software (QCTpro v 5.1.3).