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Canadian Journal of Gastroenterology & Hepatology logoLink to Canadian Journal of Gastroenterology & Hepatology
. 2016 Nov 20;2016:1468106. doi: 10.1155/2016/1468106

Corrigendum to “Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy”

Nwe Ni Than 1,2, Hannah C Jeffery 1, Ye H Oo 1,2,*
PMCID: PMC5136383  PMID: 27990413

In the article titled “Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy” [1], the word “adenosis” is misspelled in the legend of Figure  1 and should be corrected as “adenosine.” The figure's legend is corrected as follows.

Figure 1.

Figure 1

Pathogenesis of autoimmune hepatitis. Both effector T cells (CD4, CD8) and regulatory T cells (Treg) are recruited to inflamed autoimmune hepatitis liver via hepatic sinusoids. T effector cells lead to apoptosis of hepatocytes via CD95 ligand (dead ligand) expressed on them, which binds to CD95 on the hepatocytes. This killing action of T effector cells is regulated by regulatory T cells, which suppress proliferation and cytokine secretion of effector T cells. Plasma cells are also involved in immune-pathogenesis and they secrete immunoglobulin. Liver infiltrated T effector cells consist of Th17, Th1, and cytotoxic T cells. Th1 cells have T bet transcription factor; Th17 cells have transcription factor RORc. Cytotoxic T cells secrete IFN, TNF, granzyme, and perforins. Regulatory T cells (Treg = CD4CD25highCD127low) express liver tissue homing chemokine receptor CXCR3, which binds to its ligands CXCL9-11 expressed on inflamed hepatic sinusoid, hepatocytes, and bile ducts. Treg also expresses its functional markers CTLA4 (interacting with CD80/CD86 on dendritic cells). Dendritic cells secrete chemokine CCL22, which binds to chemokine receptor CCR4 on the regulatory T cells. CD39 on the Treg can generate immunosuppressive adenosine from ATP in the hepatic microenvironment. IL-2, which acts on its receptor CD25, is crucial for intrahepatic Treg survival and function.

References

  • 1.Than N. N., Jeffery H. C., Oo Y. H. Autoimmune hepatitis: progress from global immunosuppression to personalised regulatory T cell therapy. Canadian Journal of Gastroenterology and Hepatology. 2016;2016:12. doi: 10.1155/2016/7181685.7181685 [DOI] [PMC free article] [PubMed] [Google Scholar]

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