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. 1993 Sep;77(9):590–596. doi: 10.1136/bjo.77.9.590

Adverse effects of topical antiglaucomatous medications on the conjunctiva.

D Broadway 1, I Grierson 1, R Hitchings 1
PMCID: PMC513958  PMID: 8218059

Abstract

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Selected References

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  1. Bonomi L., Zavarise G., Noya E., Michieletto S. Effects of timolol maleate on tear flow in human eyes. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(1):19–22. doi: 10.1007/BF02391207. [DOI] [PubMed] [Google Scholar]
  2. Brandt J. D., Wittpenn J. R., Katz L. J., Steinmann W. N., Spaeth G. L. Conjunctival impression cytology in patients with glaucoma using long-term topical medication. Am J Ophthalmol. 1991 Sep 15;112(3):297–301. doi: 10.1016/s0002-9394(14)76730-3. [DOI] [PubMed] [Google Scholar]
  3. Coakes R. L., Mackie I. A., Seal D. V. Effects of long-term treatment with timolol on lacrimal gland function. Br J Ophthalmol. 1981 Sep;65(9):603–605. doi: 10.1136/bjo.65.9.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cvetković D., Parunović A., Kontić D. Konjunktivale Veränderungen bei der lokalen langjährigen medikamentösen Therapie des Glaukoms. Fortschr Ophthalmol. 1986;83(4):407–409. [PubMed] [Google Scholar]
  5. Derous D., de Keizer R. J., de Wolff-Rouendaal D., Soudijn W. Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker. Acta Ophthalmol (Copenh) 1989 Jun;67(3):333–338. doi: 10.1111/j.1755-3768.1989.tb01883.x. [DOI] [PubMed] [Google Scholar]
  6. Duzman E., Rosen N., Lazar M. Diacetyl nadolol: 3-month ocular hypotensive effect in glaucomatous eyes. Br J Ophthalmol. 1983 Oct;67(10):668–673. doi: 10.1136/bjo.67.10.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Feldman R. M., Gross R. L., Spaeth G. L., Steinmann W. C., Varma R., Katz L. J., Wilson R. P., Moster M. R., Spiegel D. Risk factors for the development of Tenon's capsule cysts after trabeculectomy. Ophthalmology. 1989 Mar;96(3):336–341. doi: 10.1016/s0161-6420(89)32887-9. [DOI] [PubMed] [Google Scholar]
  8. Fiore P. M., Jacobs I. H., Goldberg D. B. Drug-induced pemphigoid. A spectrum of diseases. Arch Ophthalmol. 1987 Dec;105(12):1660–1663. doi: 10.1001/archopht.1987.01060120058023. [DOI] [PubMed] [Google Scholar]
  9. Gerstenberger A., Marquardt R. Die Becherzelldichte unter Pilocarpineinfluss. Fortschr Ophthalmol. 1986;83(1):46–50. [PubMed] [Google Scholar]
  10. Herreras J. M., Pastor J. C., Calonge M., Asensio V. M. Ocular surface alteration after long-term treatment with an antiglaucomatous drug. Ophthalmology. 1992 Jul;99(7):1082–1088. doi: 10.1016/s0161-6420(92)31847-0. [DOI] [PubMed] [Google Scholar]
  11. Hoffer K. J. Pemphigoid related to epinephrine treatment. Am J Ophthalmol. 1977 Apr;83(4):601–601. doi: 10.1016/0002-9394(77)90577-3. [DOI] [PubMed] [Google Scholar]
  12. KIRCHNER C. UNTERSUCHUNGEN UEBER DAS AUSMASS DER TRAENENSEKRETION BEIM MENSCHEN. Klin Monbl Augenheilkd. 1964 Apr;144:412–417. [PubMed] [Google Scholar]
  13. Kristensen E. B., Norn M. S. Benign mucous membrane pemphigoid. 1. Secretion of mucus and tears. Acta Ophthalmol (Copenh) 1974;52(2):266–281. doi: 10.1111/j.1755-3768.1974.tb00377.x. [DOI] [PubMed] [Google Scholar]
  14. Lavin M. J., Wormald R. P., Migdal C. S., Hitchings R. A. The influence of prior therapy on the success of trabeculectomy. Arch Ophthalmol. 1990 Nov;108(11):1543–1548. doi: 10.1001/archopht.1990.01070130045027. [DOI] [PubMed] [Google Scholar]
  15. Leonard J. N., Hobday C. M., Haffenden G. P., Griffiths C. E., Powles A. V., Wright P., Fry L. Immunofluorescent studies in ocular cicatricial pemphigoid. Br J Dermatol. 1988 Feb;118(2):209–217. doi: 10.1111/j.1365-2133.1988.tb01776.x. [DOI] [PubMed] [Google Scholar]
  16. Liesegang T. J. Bulbar conjunctival follicles associated with dipivefrin therapy. Ophthalmology. 1985 Feb;92(2):228–233. doi: 10.1016/s0161-6420(85)34048-4. [DOI] [PubMed] [Google Scholar]
  17. Longstaff S., Wormald R. P., Mazover A., Hitchings R. A. Glaucoma triple procedures: efficacy of intraocular pressure control and visual outcome. Ophthalmic Surg. 1990 Nov;21(11):786–793. [PubMed] [Google Scholar]
  18. Miller M. H., Rice N. S. Trabeculectomy combined with beta irradiation for congenital glaucoma. Br J Ophthalmol. 1991 Oct;75(10):584–590. doi: 10.1136/bjo.75.10.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mondino B. J. Cicatricial pemphigoid and erythema multiforme. Ophthalmology. 1990 Jul;97(7):939–952. doi: 10.1016/s0161-6420(90)32479-x. [DOI] [PubMed] [Google Scholar]
  20. Nielsen N. V., Eriksen J. S. Timolol and metoprolol in glaucoma. A comparison of the ocular hypotensive effect, local and systemic tolerance. Acta Ophthalmol (Copenh) 1981 Jun;59(3):336–346. doi: 10.1111/j.1755-3768.1981.tb02998.x. [DOI] [PubMed] [Google Scholar]
  21. Novack G. D. Ophthalmic beta-blockers since timolol. Surv Ophthalmol. 1987 Mar-Apr;31(5):307–327. doi: 10.1016/0039-6257(87)90116-0. [DOI] [PubMed] [Google Scholar]
  22. Ober M., Scharrer A., David R., Biedner B. Z., Novack G. D., Lue J. C., Robins D. S., Duzman E. Long-term ocular hypotensive effect of levobunolol: results of a one-year study. Br J Ophthalmol. 1985 Aug;69(8):593–599. doi: 10.1136/bjo.69.8.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Patten J. T., Cavanagh H. D., Allansmith M. R. Induced ocular pseudopemphigoid. Am J Ophthalmol. 1976 Aug;82(2):272–276. doi: 10.1016/0002-9394(76)90433-5. [DOI] [PubMed] [Google Scholar]
  24. Podos S. M. Pharmacology of ocular drugs: 2. Epinephrine. Ophthalmology. 1980 Jul;87(7):721–723. doi: 10.1016/s0161-6420(80)35176-2. [DOI] [PubMed] [Google Scholar]
  25. Pouliquen Y., Patey A., Foster C. S., Goichot L., Savoldelli M. Drug-induced cicatricial pemphigoid affecting the conjunctiva. Light and electron microscopic features. Ophthalmology. 1986 Jun;93(6):775–783. doi: 10.1016/s0161-6420(86)33675-3. [DOI] [PubMed] [Google Scholar]
  26. Rahi A. H., Chapman C. M., Garner A., Wright P. Pathology of practolol-induced ocular toxicity. Br J Ophthalmol. 1976 May;60(5):312–323. doi: 10.1136/bjo.60.5.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Ruskell G. L. Innervation of the conjunctiva. Trans Ophthalmol Soc U K. 1985;104(Pt 4):390–395. [PubMed] [Google Scholar]
  28. Schwab I. R., Linberg J. V., Gioia V. M., Benson W. H., Chao G. M. Foreshortening of the inferior conjunctival fornix associated with chronic glaucoma medications. Ophthalmology. 1992 Feb;99(2):197–202. doi: 10.1016/s0161-6420(92)32001-9. [DOI] [PubMed] [Google Scholar]
  29. Seetner A., Morin J. D. Healing of trabeculectomies in rabbits. Can J Ophthalmol. 1979 Apr;14(2):121–125. [PubMed] [Google Scholar]
  30. Sherwood M. B., Grierson I., Millar L., Hitchings R. A. Long-term morphologic effects of antiglaucoma drugs on the conjunctiva and Tenon's capsule in glaucomatous patients. Ophthalmology. 1989 Mar;96(3):327–335. doi: 10.1016/s0161-6420(89)32888-0. [DOI] [PubMed] [Google Scholar]
  31. Smith D. L., Skuta G. L., Kincaid M. C., Rabbani R., Cruess D. F., Kao S. F. The effects of glaucoma medications on Tenon's capsule and conjunctiva in the rabbit. Ophthalmic Surg. 1991 Jun;22(6):336–340. [PubMed] [Google Scholar]
  32. Steuhl K. P., Knorr M., Frohn A., Thiel H. J. Uber den Einfluss antiglaukomatöser Augentropfen auf die Zelldifferenzierung der Konjunktiva. Fortschr Ophthalmol. 1991;88(6):865–869. [PubMed] [Google Scholar]
  33. Strempel I. Immediatwirkung topischer beta-Blocker auf die "Breakup time". Ophthalmologica. 1986;192(1):11–16. doi: 10.1159/000309605. [DOI] [PubMed] [Google Scholar]
  34. Strempel I. The influence of topical beta-blockers on the breakup time. Ophthalmologica. 1984;189(3):110–115. doi: 10.1159/000309394. [DOI] [PubMed] [Google Scholar]
  35. THEODORE F. H. Drug sensitivities and irritations of the conjunctiva. J Am Med Assoc. 1953 Jan 3;151(1):25–30. [PubMed] [Google Scholar]
  36. Takahashi N. A new method evaluating quantitative time-dependent cytotoxicity of ophthalmic solutions in cell culture. Beta-adrenergic blocking agents. Graefes Arch Clin Exp Ophthalmol. 1983;220(6):264–267. doi: 10.1007/BF00231353. [DOI] [PubMed] [Google Scholar]
  37. Takahashi N. Cytotoxicity of mercurial preservatives in cell culture. Ophthalmic Res. 1982;14(1):63–69. doi: 10.1159/000265175. [DOI] [PubMed] [Google Scholar]
  38. Takahashi N. Quantitative cytotoxicity of preservatives evaluated in cell culture with Chang's human conjunctival cells--effect of temperature on cytotoxicity. Jpn J Ophthalmol. 1982;26(2):234–238. [PubMed] [Google Scholar]
  39. Takahashi N. [Cytotoxic effects of antiglaucoma agents on cultured human conjunctival cells (author's transl)]. Nippon Ganka Gakkai Zasshi. 1981 Aug 10;85(8):1046–1052. [PubMed] [Google Scholar]
  40. Tseng S. C., Maumenee A. E., Stark W. J., Maumenee I. H., Jensen A. D., Green W. R., Kenyon K. R. Topical retinoid treatment for various dry-eye disorders. Ophthalmology. 1985 Jun;92(6):717–727. doi: 10.1016/s0161-6420(85)33968-4. [DOI] [PubMed] [Google Scholar]
  41. Van Buskirk E. M. Adverse reactions from timolol administration. Ophthalmology. 1980 May;87(5):447–450. doi: 10.1016/s0161-6420(80)35215-9. [DOI] [PubMed] [Google Scholar]
  42. Van Buskirk E. M. Corneal anesthesia after timolol maleate therapy. Am J Ophthalmol. 1979 Oct;88(4):739–743. doi: 10.1016/0002-9394(79)90675-5. [DOI] [PubMed] [Google Scholar]
  43. Varga M., Follmann P. Feinstrukturelle Untersuchungen der Bindehautoberfläche nach Langzeitbehandlung mit Timolol. Fortschr Ophthalmol. 1986;83(2):155–157. [PubMed] [Google Scholar]
  44. Williams D. E., Nguyen K. D., Shapourifar-Tehrani S., Kitada S., Lee D. A. Effects of timolol, betaxolol, and levobunolol on human tenon's fibroblasts in tissue culture. Invest Ophthalmol Vis Sci. 1992 Jun;33(7):2233–2241. [PubMed] [Google Scholar]
  45. Wilson F. M., 2nd Adverse external ocular effects of topical ophthalmic medications. Surv Ophthalmol. 1979 Sep-Oct;24(2):57–88. doi: 10.1016/0039-6257(79)90125-5. [DOI] [PubMed] [Google Scholar]
  46. Wilson F. M., 2nd Adverse external ocular effects of topical ophthalmic therapy: an epidemiologic, laboratory, and clinical study. Trans Am Ophthalmol Soc. 1983;81:854–965. [PMC free article] [PubMed] [Google Scholar]
  47. Wright P. Cicatrizing conjunctivitis. Trans Ophthalmol Soc U K. 1986;105(Pt 1):1–17. [PubMed] [Google Scholar]
  48. Wright P. Squamous metaplasia or epidermalization of the conjunctiva as an adverse reaction to topical medication. Trans Ophthalmol Soc U K. 1979 Jul;99(2):244–246. [PubMed] [Google Scholar]
  49. Wright P. Untoward effects associated with practolol administration: oculomucocutaneous syndrome. Br Med J. 1975 Mar 15;1(5958):595–598. doi: 10.1136/bmj.1.5958.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Young T. L., Higginbotham E. J., Zou X. L., Farber M. D. Effects of topical glaucoma drugs on fistulized rabbit conjunctiva. Ophthalmology. 1990 Nov;97(11):1423–1427. doi: 10.1016/s0161-6420(90)32392-8. [DOI] [PubMed] [Google Scholar]
  51. van Joost T., Middelkamp J., Ros F. E. Dermatitis as a side-effect of long-term topical treatment with certain beta-blocking agents. Br J Dermatol. 1979 Aug;101(2):171–177. doi: 10.1111/j.1365-2133.1979.tb05604.x. [DOI] [PubMed] [Google Scholar]

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