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. Author manuscript; available in PMC: 2016 Dec 8.
Published in final edited form as: Leukemia. 2016 May 23;30(12):2302–2311. doi: 10.1038/leu.2016.139

Fig. 6. CREB Inhibition Induces Cell Cycle Arrest.

Fig. 6

A) Cell cycle phase analysis of KG-1 cells treated with XX-650-23 showed G1/S transition block and delayed S-phase progression. Data represent the percentages of cell populations residing at each cell cycle stage and is expressed as mean ± SEM (n = 3). B) CyTOF analysis of AML patient samples also showed a reduction of cells in G2 and S phase following XX-650-23 treatment. C) CREB-regulated genes important for cell cycle progression through G1/S and S were downregulated. CCNA2 and CCND1 expression was decreased following 24 hours of treatment, while RFC3 expression decreased following 48 hours of treatment. Data are graphed as mean ± SEM (n = 3), *p < 0.05; **p < 0.01, t-test.