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. 1991 Apr 15;88(8):3339–3342. doi: 10.1073/pnas.88.8.3339

Interleukin 4 promotes expression of mast cell ICAM-1 antigen.

P Valent 1, D Bevec 1, D Maurer 1, J Besemer 1, F Di Padova 1, J H Butterfield 1, W Speiser 1, O Majdic 1, K Lechner 1, P Bettelheim 1
PMCID: PMC51442  PMID: 1673030

Abstract

Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact-dependent regulation of immune cells in inflamed tissues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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