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. 1991 Apr 15;88(8):3421–3425. doi: 10.1073/pnas.88.8.3421

Human response against NP-4, a mouse antibody to carcinoembryonic antigen: human anti-idiotype antibodies mimic an epitope on the tumor antigen.

M J Losman 1, H J Hansen 1, R M Sharkey 1, D M Goldenberg 1, M Monestier 1
PMCID: PMC51459  PMID: 1707540

Abstract

Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also reactive with the CEA epitope recognized by NP-4. These results indicate that human Ab2 to NP-4 can antigenically mimic the CEA epitope recognized by NP-4.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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