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. 1991 Apr 15;88(8):3494–3497. doi: 10.1073/pnas.88.8.3494

Global and local metric geometry of ligand binding thermodynamics.

E Di Cera 1, J Wyman 1
PMCID: PMC51474  PMID: 11607177

Abstract

An abstract metric representation of ligand binding thermodynamics reveals the basic connections between the classical thermodynamic theory of binding and linkage [Wyman, J. (1964) Adv. Protein Chem. 19, 223-286] and its site-specific formulation [Di Cera, E. (1990) Biophys. Chem. 37, 147-164]. These two approaches are limit cases of a general metric formulation of binding and linkage that also includes a number of intermediate "mixed" representations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Di Cera E., Gill S. J., Wyman J. Canonical formulation of linkage thermodynamics. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5077–5081. doi: 10.1073/pnas.85.14.5077. [DOI] [PMC free article] [PubMed] [Google Scholar]
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