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. Author manuscript; available in PMC: 2017 Dec 7.
Published in final edited form as: Neuron. 2016 Nov 17;92(5):1049–1062. doi: 10.1016/j.neuron.2016.10.030

Figure 7. One-hour food deprivation increases threat tolerance by inhibiting RIM activity and suppressing RIM-ASH tyraminergic potentiation.

Figure 7

(A) Schematic depicting prediction that exogenous tyramine increases threat sensitivity. Exogenous tyramine is predicted to reverse the effects of suppression of the RIM-ASH positive feedback loop on threat sensitivity. Yellow represents strong activity, while blue represents weak activity. Thickness of solid lines represents strength of signals, and dashed lines represent inactive signals.

(B) Effect of exogenous tyramine on multisensory decisions of wild-type, tdc-1 null-mutant, and tyra-2 null-mutant worms.

(C) Effect of exogenous tyramine on multisensory decisions of one-hour food-deprived wild-type and tyra-2 null-mutant worms.

(D) Schematic depicting prediction that inhibition of RIM increases threat tolerance. Inhibition of RIM expressing His-Cl with exogenous histamine is predicted to increase threat tolerance and mimic one hour of food deprivation.

(E) Effect of 0, 10 mM, and 30 mM histamine on multisensory decision balance of worms expressing RIM::His-Cl.

(F) Effect of 0 and 10 mM histamine on multisensory decision balance of one-hour food-deprived worms expressing RIM::His-Cl.