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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Neuropharmacology. 2016 Oct 11;113(Pt A):260–270. doi: 10.1016/j.neuropharm.2016.07.030

Figure 2. Effects of lithium alone and in combination with GBR12909 in C57BL/6 mice or in DAT WT and KD mice in the Probabilistic Reversal Learning Task.

Figure 2

Lithium at 1 g/l increased the number of trials needed to reach criterion in C57BL/6 mice while lithium at 0.6 g/l did not change the number of trials to criterion compared to water treated mice (A). Lithium at 0.6g/l and 1 g/l did not significantly reduced the number reversals made by C57BL/6 mice compared to water treated mice (B). GBR12909 (13 mg/kg) nor lithium had any significant effects on the number of trials to criterion (C). The number of reversals was greatly increased by GBR12909 treatment in water pre-treated mice. Lithium (0.6 g/l) blocked this increase in reversals (D). Treatment with lithium increased the number of trials needed to reach initial criterion in DAT KD mice but not in WT mice (E). Lithium treatment significantly lowered reversals in DAT KD mice compared to those treated with water but this effect was not seen in WT mice (F).

Data are presented as mean ± S.E.M. * p<0.05 when compared to vehicle. # p<0.05 when compared to DAT KD with vehicle treatment.