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. 2016 May 9;13(6):669–676. doi: 10.3109/15412555.2016.1170111

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Rate of moderate-to-severe COPD exacerbations (A) overall (individual studies and pooled analyses)^a and (B) stratified by GOLD group (pooled analysis). ^aExacerbations analyses from the individual ACLIFORM and AUGMENT studies are reported for the ITT-exacerbations populations of the aclidinium monotherapy and placebo arms only (579 and 669 patients, respectively; all patients who received at least one dose of the study medication), as specified in the study protocols and published previously (20,32); pooled analyses include data from the ITT populations (577 and 668 patients, respectively; all patients who received at least one dose of the study medication and had a baseline and ≥1 post-baseline FEV₁ assessment) for consistency with the ACCORD I, ACCORD II and ATTAIN study populations. Percentages are the proportion of all GOLD-classified patients (N = 2,459) in each GOLD group. CI, confidence interval; GOLD, Global initiative for chronic Obstructive Lung Disease; ITT, intent-to-treat; RR, rate ratio; N, number of patients in aclidinium 400 μg and placebo groups.