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Journal of Virology logoLink to Journal of Virology
. 1976 Jan;17(1):43–50. doi: 10.1128/jvi.17.1.43-50.1976

Quantitative Analysis of the Rescue of RNA Sequences by Mammalian Type C Viruses

Robert J Goldberg 1, Reuven Levin 1, Wade P Parks 1, Edward M Scolnick 1
PMCID: PMC515386  PMID: 173892

Abstract

The specificity and quantitation of the rescue of RNA sequences by mammalian type C viruses has been investigated. Type C viruses can package with specificity only type C viral RNA. Type C viruses do not encapsidate with comparable efficiency either type B viral or cellular globin mRNA. Conversely, a non-type C mammalian retravirus, MP-MV, cannot encapsidate type C RNA. A revertant of Kirsten sarcoma virus (Ki-SV)-transformed nonproducer cells which fails to rescue biologically active Ki-SV after superinfection with helper virus had no detectable intracellular Ki-SV -specific RNA. The results suggest specific mechanisms by which type C viral proteins can package type C viral RNA and provide an approach to classifying RNA of potentially defective endogenous retraviruses as type C in origin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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