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. 1976 Jan;17(1):127–131. doi: 10.1128/jvi.17.1.127-131.1976

Origin of the Polyoma Virus-Associated Endonuclease 1

Janis McMillen a, Melvin S Center a, Richard A Consigli a
PMCID: PMC515395  PMID: 173877

Abstract

Endonuclease activity can be found associated with highly purified preparations of polyoma virus. Evidence has been obtained that this enzyme is not an integral part of the virus but is contributed by the fetal calf serum used in maintenance of polyoma-infected cells. This finding is based on: (i) the lack of virion-associated endonuclease activity when virus is produced using serum-free media and (ii) the production of polyoma antibody which neutralizes fetal calf serum endonuclease activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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