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. 1976 Feb;17(2):605–613. doi: 10.1128/jvi.17.2.605-613.1976

Kinetics of utilization of Sendai virus RNA and protein in the process of virion assembly.

N G Famulari, E Fleissner
PMCID: PMC515451  PMID: 176433

Abstract

The synthesis of the 50S genomic RNA and strucural proteins of Sendai virus was examined with respect to their utilization in virus assembly. It was found that during a single cycle of infection, 50S RNA was synthesized before the structural proteins and that both RNA and protein were synthesized 2 to 4 h before their appearance in released virions. Pulse-chase labeling indicated that the NP and P proteins synthesized early and the M and F proteins synthesized late were preferentially incorporated into virus relative to the other viral proteins. The kinetics of incorporation of pulse-labeled NP protein suggested that it was withdrawn from a relatively large pool whereas the M protein appeared to be present in a relatively small pool in the cytoplasm. Further, it was possible to chase pulse-labeled M protein, but not NP protein, from the cell during an 8-h time period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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