Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

Journal of Virology logoLink to Journal of Virology
. 1976 Mar;17(3):1063–1067. doi: 10.1128/jvi.17.3.1063-1067.1976

Formation of an infectious virus-antibody complex with Rous sarcoma virus and antibodies directed against the major virus glycoprotein.

M J Schlesinger
PMCID: PMC515508  PMID: 56458

Abstract

Preparations of Rous sarcoma virus (RSV) can form an infectious viral-antibody complex with antibodies raised against the major glycoprotein, gp85, isolated from avian myeloblastosis virus and Prague-RSV subgroup C. Binding of anti-gp85 antibodies to RSV can be demonstrated by the inhibition of focus-forming activity after addition of goat anti-rabbit immunoglobulin and by a shift in density of virions treated with anti-gp85 serum. Group- rather than subgroup- specific regions of viral gp85 appear to be the site of binding for infectious complex.

Full text

PDF
1063

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolognesi D. P., Bauer H., Gelderblom H., Hüper G. Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope. Virology. 1972 Mar;47(3):551–566. doi: 10.1016/0042-6822(72)90545-4. [DOI] [PubMed] [Google Scholar]
  2. Bolognesi D. P., Ishizaki R., Hüper G., Vanaman T. C., Smith R. E. Immunological properties of avian oncornavirus polypeptides. Virology. 1975 Apr;64(2):349–357. doi: 10.1016/0042-6822(75)90111-7. [DOI] [PubMed] [Google Scholar]
  3. Bolognesi D. P., Luftig R., Shaper J. H. Localization of RNA tumor virus polypeptides. I. Isolation of further virus substructures. Virology. 1973 Dec;56(2):549–564. doi: 10.1016/0042-6822(73)90057-3. [DOI] [PubMed] [Google Scholar]
  4. Cuatrecasas P., Tell G. P. Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors. Proc Natl Acad Sci U S A. 1973 Feb;70(2):485–489. doi: 10.1073/pnas.70.2.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Duesberg P. H., Martin G. S., Vogt P. K. Glycoprotein components of avian and murine RNA tumor viruses. Virology. 1970 Aug;41(4):631–646. doi: 10.1016/0042-6822(70)90428-9. [DOI] [PubMed] [Google Scholar]
  6. Fleissner E. Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. I. Avian leukemia-sarcoma viruses. J Virol. 1971 Nov;8(5):778–785. doi: 10.1128/jvi.8.5.778-785.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Green R. W., Bolognesi D. P. Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses. Anal Biochem. 1974 Jan;57(1):108–117. doi: 10.1016/0003-2697(74)90057-8. [DOI] [PubMed] [Google Scholar]
  8. Halpern M. S., Bolognesi D. P., Friis R. R., Mason W. S. Expression of the Major Viral Glycoprotein of Avian Tumor Virus in Cells of chf(+) Chicken Embryos. J Virol. 1975 May;15(5):1131–1140. doi: 10.1128/jvi.15.5.1131-1140.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Herman A. C., Green R. W., Bolognesi D. P., Vanaman T. C. Comparative chemical properties of avian oncornavirus polypeptides. Virology. 1975 Apr;64(2):339–348. doi: 10.1016/0042-6822(75)90110-5. [DOI] [PubMed] [Google Scholar]
  10. Hirsch M. S., Allison A. C., Harvey J. J. Immune complexes in mice infected neonatally with Moloney leukaemogenic and murine sarcoma viruses. Nature. 1969 Aug 16;223(5207):739–740. doi: 10.1038/223739a0. [DOI] [PubMed] [Google Scholar]
  11. Hung P. P., Robinson H. L., Robinson W. S. Isolation and characterization of proteins from Rous sarcoma virus. Virology. 1971 Jan;43(1):251–266. doi: 10.1016/0042-6822(71)90243-1. [DOI] [PubMed] [Google Scholar]
  12. Notkins A. L. Infectious virus-antibody complexes: interaction with anti-immunoglobulins, complement, and rheumatoid factor. J Exp Med. 1971 Sep 1;134(3 Pt 2):41s–51s. [PubMed] [Google Scholar]
  13. Oldstone M. B., Aoki T., Dixon F. J. The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance (AKR mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes). Proc Natl Acad Sci U S A. 1972 Jan;69(1):134–138. doi: 10.1073/pnas.69.1.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Oldstone M. B., Dixon F. J. Immune complex disease in chronic viral infections. J Exp Med. 1971 Sep 1;134(3 Pt 2):32s–40s. [PubMed] [Google Scholar]
  15. Robinson W. S., Hung P., Robinson H. L., Ralph D. D. Proteins of avian tumor viruses with different coat antigens. J Virol. 1970 Nov;6(5):695–698. doi: 10.1128/jvi.6.5.695-698.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rohrschneider L., Bauer H., Bolognesi D. P. Group-specific antigenic determinants of the large envelope glycoprotein of avian oncornaviruses. Virology. 1975 Sep;67(1):234–241. doi: 10.1016/0042-6822(75)90420-1. [DOI] [PubMed] [Google Scholar]
  17. Scheele C. M., Hanafusa H. Electrophoretic analysis of the RNA of avian tumor viruses. Virology. 1972 Dec;50(3):753–764. doi: 10.1016/0042-6822(72)90429-1. [DOI] [PubMed] [Google Scholar]
  18. Schlesinger M. J., Schlesinger S., Burge B. W. Identification of a second glycoprotein in Sindbis virus. Virology. 1972 Feb;47(2):539–541. doi: 10.1016/0042-6822(72)90298-x. [DOI] [PubMed] [Google Scholar]
  19. Tozawa H., Bauer H., Graf T., Gelderblom H. Strain-specific antigen of the avian leukosis sarcoma virus group. I. Isolation and immunological characterization. Virology. 1970 Mar;40(3):530–539. doi: 10.1016/0042-6822(70)90196-0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES