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. 1976 May;18(2):776–782. doi: 10.1128/jvi.18.2.776-782.1976

Acceleration of transformation of rat embryo cells by rat type C virus.

S Rasheed, A E Freeman, M B Gardner, R J Huebner
PMCID: PMC515606  PMID: 178908

Abstract

Sprague-Dawley and Fischer rat embryo cells became spontaneously transformed about 20 passages after release of endogenous ecotropic type C virus (SD-RaLV and F-RaLV). The virus-producing transformed cells showed loss of contact inhibition, increased growth rate, and tumorigenicity in vivo. Exogenous infection of other Fischer rat embryo cultures in early passage with SD-RaLV and F-RaLV markedly accelerated their rates of transformation.

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Selected References

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