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. 1977 Mar;21(3):1074–1078. doi: 10.1128/jvi.21.3.1074-1078.1977

Evidence for recombination between N- and B-tropic murine leukemia viruses.

N Hopkins, J Schindler, P D Gottlieb
PMCID: PMC515647  PMID: 66326

Abstract

After co-infection of Sc-1 cells with N- and B-tropic murine leukemia viruses that differ in their XC plaque morphology, Hopkins et al. (1976) obtained viruses, designated XLP-N, that appeared to be recombinants, since they possess the N-tropism of one parent and the XC plaque morphology of the other (the B-tropic virus) parent. Here we present evidence, based on antigenicity and electrophoretic mobility, that some clonal isolates of XLP-N have inherited gp70 gene of their B-tropic virus parent. In addition to providing evidence that XLP-N viruses are recombinants, the fact that an N-tropic virus may apparently possess a gp70 derived from a B-tropic virus provides evidence, which is in agreement with the findings of others (Huang et al., 1973; Krontiris et al., 1973) that the N- or B-tropism of murine leukemia virus does not reside in gp70.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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