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. 1977 Jun;22(3):626–633. doi: 10.1128/jvi.22.3.626-633.1977

Donation of N- or B-tropic phenotype to NB-tropic murine leukemia virus during mixed infections.

S V Kashmiri, A Rein, R H Bassin, B I Gerwin, S Gisselbrecht
PMCID: PMC515761  PMID: 195081

Abstract

The IC isolate of Moloney murine leukemia virus (MuLV), which is NB-tropic, was grown in cells producing conditionally defective or defective virus particles derived from N- or B-tropic MuLV. The infectious MuLV that was then released was found to be sensitive to Fv-1 restriction but produced NB-tropic progeny upon passage. These results indicate that this NB-tropic MuLV can acquire sensitivity to Fv-1 restriction by phenotypic mixing with N- or B-tropic MuLV. It is thus suggested that NB-tropic MuLV is insensitive to Fv-1 restriction simply because it lacks the determinants of tropism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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