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. 1977 Jul;23(1):106–109. doi: 10.1128/jvi.23.1.106-109.1977

Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

B A Taylor, H G Bedigian, H Meier
PMCID: PMC515805  PMID: 196096

Abstract

Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chapman V. M. 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci. Biochem Genet. 1975 Dec;13(11-12):849–856. doi: 10.1007/BF00484415. [DOI] [PubMed] [Google Scholar]
  2. Declève A., Niwa O., Gelmann E., Kaplan H. S. Replication kinetics of N- and B-tropic murine leukemia viruses on permissive and nonpermissive cells in vitro. Virology. 1975 Jun;65(2):320–332. doi: 10.1016/0042-6822(75)90038-0. [DOI] [PubMed] [Google Scholar]
  3. FINLAYSON J. S., POTTER M., RUNNER C. R. ELECTROPHORETIC VARIATION AND SEX DIMORPHISM OF THE MAJOR URINARY PROTEIN COMPLEX IN INBRED MICE: A NEW GENETIC MARKER. J Natl Cancer Inst. 1963 Jul;31:91–107. [PubMed] [Google Scholar]
  4. Finlayson J. S., Hudson D. M., Armstrong B. L. Location of the Mup-a locus on mouse linkage group 8. Genet Res. 1969 Dec;14(3):329–331. doi: 10.1017/s0016672300002159. [DOI] [PubMed] [Google Scholar]
  5. Haldane J B, Waddington C H. Inbreeding and Linkage. Genetics. 1931 Jul;16(4):357–374. doi: 10.1093/genetics/16.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture. J Virol. 1969 Feb;3(2):126–132. doi: 10.1128/jvi.3.2.126-132.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Huang A. S., Besmer P., Chu L., Baltimore D. Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses. J Virol. 1973 Sep;12(3):659–662. doi: 10.1128/jvi.12.3.659-662.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hudson D. M., Finlayson J. S., Potter M. Linkage of one component of the major urinary protein complex of mice to the brown coat color locus. Genet Res. 1967 Oct;10(2):195–198. doi: 10.1017/s0016672300010922. [DOI] [PubMed] [Google Scholar]
  9. Hutton J. J., Coleman D. L. Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem Genet. 1969 Oct;3(5):517–523. doi: 10.1007/BF00485612. [DOI] [PubMed] [Google Scholar]
  10. Jolicoeur P., Baltimore D. Effect of Fv-1 gene product on proviral DNA formation and integration in cells infected with murine leukemia viruses. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2236–2240. doi: 10.1073/pnas.73.7.2236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jolicoeur P., Baltimore D. Effect of the Fv-1 locus on the titration of murine leukemia viruses. J Virol. 1975 Dec;16(6):1593–1598. doi: 10.1128/jvi.16.6.1593-1598.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Klement V., Rowe W. P., Hartley J. W., Pugh W. E. Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture. Proc Natl Acad Sci U S A. 1969 Jul;63(3):753–758. doi: 10.1073/pnas.63.3.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lilly F. Susceptibility to two strains of Friend leukemia virus in mice. Science. 1967 Jan 27;155(3761):461–462. doi: 10.1126/science.155.3761.461. [DOI] [PubMed] [Google Scholar]
  14. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. IV. Dose-response relationships in Fv-1-sensitive and resistant cell cultures. Virology. 1975 Jun;65(2):333–342. doi: 10.1016/0042-6822(75)90039-2. [DOI] [PubMed] [Google Scholar]
  16. Pincus T., Rowe W. P., Lilly F. A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. J Exp Med. 1971 Jun 1;133(6):1234–1241. doi: 10.1084/jem.133.6.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rein A., Kashmiri S. V., Bassin R. H., Gerwin B. L., Duran-Troise G. Phenotypic mixing between N- and B-tropic murine leukemia viruses: infectious particles with dual sensitivity to Fv-1 restriction. Cell. 1976 Mar;7(3):373–379. doi: 10.1016/0092-8674(76)90166-5. [DOI] [PubMed] [Google Scholar]
  18. Roderick T. H., Ruddle F. H., Chapman V. M., Shows T. B. Biochemical polymorphisms in feral and inbred mice (mus musculus). Biochem Genet. 1971 Oct;5(5):457–466. doi: 10.1007/BF00487135. [DOI] [PubMed] [Google Scholar]
  19. Rowe W. P., Humphrey J. B., Lilly F. A major genetic locus affecting resistance to infection with murine leukemia viruses. 3. Assignment of the Fv-1 locus to linkage group 8 of the mouse. J Exp Med. 1973 Mar 1;137(3):850–853. doi: 10.1084/jem.137.3.850. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rowe W. P., Sato H. Genetic mapping of the Fv-1 lcous of the mouse. Science. 1973 May 11;180(4086):640–641. doi: 10.1126/science.180.4086.640. [DOI] [PubMed] [Google Scholar]
  21. Schuh V., Blackstein M. E., Axelrad A. A. Inherited resistance to N- and B-tropic murine leukemia viruses in vitro: titration patterns in strains SIM and SIM.R congenic at the Fv-1 locus. J Virol. 1976 May;18(2):473–480. doi: 10.1128/jvi.18.2.473-480.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sveda M. M., Soeiro R. Host restriction of Friend leukemia virus: synthesis and integration of the provirus. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2356–2360. doi: 10.1073/pnas.73.7.2356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Taylor B. A., Bailey D. W., Cherry M., Riblet R., Weigert M. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644–646. doi: 10.1038/256644a0. [DOI] [PubMed] [Google Scholar]
  24. Taylor B. A. Genetic relationships between inbred strains of mice. J Hered. 1972 Mar-Apr;63(2):83–86. doi: 10.1093/oxfordjournals.jhered.a108235. [DOI] [PubMed] [Google Scholar]

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