Abstract
Cell fusion induced by syn mutants of herpes simplex virus type 1 is inhibited by NH4Cl. The inhibition of fusion is both rapid and rapidly reversible and apprears to be due to the NH4+ ion. Virus production was not significantly altered by NH4Cl, although cell growth was greatly diminished.
Full text
PDF![213](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78e/515818/caed6a854ce3/jvirol00211-0223.png)
![214](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78e/515818/584a52199d79/jvirol00211-0224.png)
![215](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e78e/515818/30d45f320f2a/jvirol00211-0225.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bratt M. A., Gallaher W. R. Preliminary analysis of the requirements for fusion from within and fusion from without by Newcastle disease virus. Proc Natl Acad Sci U S A. 1969 Oct;64(2):536–543. doi: 10.1073/pnas.64.2.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown S. M., Ritchie D. A., Subak-Sharpe J. H. Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. J Gen Virol. 1973 Mar;18(3):329–346. doi: 10.1099/0022-1317-18-3-329. [DOI] [PubMed] [Google Scholar]
- GRAY A., TOKUMARU T., SCOTT T. F. M. Different cytopathogenic effects observed in HeLa cells infected with herpes simplex virus. Arch Gesamte Virusforsch. 1958;8(1):59–76. doi: 10.1007/BF01242313. [DOI] [PubMed] [Google Scholar]
- HOGGAN M. D., ROIZMAN B. The isolation and properties of a variant of Herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody. Am J Hyg. 1959 Sep;70:208–219. doi: 10.1093/oxfordjournals.aje.a120071. [DOI] [PubMed] [Google Scholar]
- Knowles R. W., Person S. Effects of 2-deoxyglucose, glucosamine, and mannose on cell fusion and the glycoproteins of herpes simplex virus. J Virol. 1976 May;18(2):644–651. doi: 10.1128/jvi.18.2.644-651.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Person S., Knowles R. W., Read G. S., Warner S. C., Bond V. C. Kinetics of cell fusion induced by a syncytia-producing mutant of herpes simplex virus type I. J Virol. 1975 Jan;17(1):183–190. doi: 10.1128/jvi.17.1.183-190.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WHEELER C. E., Jr BIOLOGIC COMPARISON OF A SYNCYTIAL AND A SMALL GIANT CELL-FORMING STRAIN OF HERPES SIMPLEX. J Immunol. 1964 Nov;93:749–756. [PubMed] [Google Scholar]