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. 1977 Sep;23(3):578–586. doi: 10.1128/jvi.23.3.578-586.1977

Endogenous RD-114 virus genome expression in malignant tissues of domestic cats.

H L Niman, M B Gardner, J R Stephenson, P Roy-Burman
PMCID: PMC515868  PMID: 197261

Abstract

Endogenous xenotropic cat type C virus (RD-114)- and infectious feline leukemia virus (FeLV)-specific gene expressions were measured in spontaneous sarcomas carcinomas, and nonmalignant cat tissues by molecular hybridization for virus-specific RNA and competition radio-immunoassays for the major internal protein (p30) of these two viruses. The results indicate that RD-114 gene expression in sarcomas and carcinomas at both RNA and p30 levels is significantly higher than histologically normal tissues from cats free of cancer. In contrast, the levels of FeLV viral RNA and p30 are fount to be low or undetectable in the majority of these tumored and normal tissues examined. Whereas variability in the amounts of RD-114 OR FeLV RNA and p30 expressed is found in tissues from different cats, their expression is fairly uniform in multiple malignant tissues of the same cat. The finding of widespread occurrence of elevated RD-114 gene expression in sarcomas and carcinomas is consistent with our similar observation with natural lymphomas of domestic cats and suggests that expression of certain functions of this endogenous virus may be etiologically involved in the development of many different spontaneous neoplasms of cats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ando T. A nuclease specific for heat-denatured DNA in isolated from a product of Aspergillus oryzae. Biochim Biophys Acta. 1966 Jan 18;114(1):158–168. doi: 10.1016/0005-2787(66)90263-2. [DOI] [PubMed] [Google Scholar]
  2. Baluda M. A., Roy-Burman P. Partial characterization of RD114 virus by DNA-RNA hybridization studies. Nat New Biol. 1973 Jul 11;244(132):59–62. doi: 10.1038/newbio244059a0. [DOI] [PubMed] [Google Scholar]
  3. Benveniste R. E., Sherr C. J., Todaro G. J. Evolution of type C viral genes: origin of feline leukemia virus. Science. 1975 Nov 28;190(4217):886–888. doi: 10.1126/science.52892. [DOI] [PubMed] [Google Scholar]
  4. Benveniste R. E., Todaro G. J. Evolution of C-type viral genes: inheritance of exogenously acquired viral genes. Nature. 1974 Dec 6;252(5483):456–459. doi: 10.1038/252456a0. [DOI] [PubMed] [Google Scholar]
  5. Benveniste R. E., Todaro G. J. Homology between type-C viruses of various species as determined by molecular hybridization. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3316–3320. doi: 10.1073/pnas.70.12.3316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fan H., Baltimore D. RNA metabolism of murine leukemia virus: detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA. J Mol Biol. 1973 Oct 15;80(1):93–117. doi: 10.1016/0022-2836(73)90235-0. [DOI] [PubMed] [Google Scholar]
  7. Fischinger P. J., Peebles P. T., Nomura S., Haapala D. K. Isolation of RD-114-like oncornavirus from a cat cell line. J Virol. 1973 Jun;11(6):978–985. doi: 10.1128/jvi.11.6.978-985.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fujinaga K., Rankin A., Yamazaki H., Sekikawa K., Bragdon J., Green M. RD-114 virus: analysis of viral gene sequences in feline and human cells by DNA-DNA reassociation kinetics and RNA-DNA hybridization. Virology. 1973 Dec;56(2):484–495. doi: 10.1016/0042-6822(73)90051-2. [DOI] [PubMed] [Google Scholar]
  9. Gardner M. B., Brown J. C., Charman H. P., Stephenson J. R., Rongey R. W., Hauser D. E., Diegmann F., Howard E., Dworsky R., Gilden R. V. FeLV epidemiology in Los Angeles cats: Appraisal of detection methods. Int J Cancer. 1977 Apr 15;19(4):581–589. doi: 10.1002/ijc.2910190420. [DOI] [PubMed] [Google Scholar]
  10. Gillespie D., Gillespie S., Gallo R. C., East J. L., Dmochowski L. Genetic origin of RD114 and other RNA tumour viruses assayed by molecular hybridization. Nat New Biol. 1973 Jul 11;244(132):51–54. doi: 10.1038/newbio244051a0. [DOI] [PubMed] [Google Scholar]
  11. Hardy W. D., Jr, Hess P. W., MacEwen E. G., McClelland A. J., Zuckerman E. E., Essex M., Cotter S. M., Jarrett O. Biology of feline leukemia virus in the natural environment. Cancer Res. 1976 Feb;36(2 Pt 2):582–588. [PubMed] [Google Scholar]
  12. Hardy W. D., Jr, Old L. J., Hess P. W., Essex M., Cotter S. Horizontal transmission of feline leukaemia virus. Nature. 1973 Aug 3;244(5414):266–269. doi: 10.1038/244266a0. [DOI] [PubMed] [Google Scholar]
  13. Hino S., Stephenson J. R., Aaronson S. A. Antigenic determinants of the 70,000 molecular weight glycoprotein of woolly monkey type C RNA virus. J Immunol. 1975 Oct;115(4):922–927. [PubMed] [Google Scholar]
  14. Holmes D. S., Bonner J. Preparation, molecular weight, base composition, and secondary structure of giant nuclear ribonucleic acid. Biochemistry. 1973 Jun 5;12(12):2330–2338. doi: 10.1021/bi00736a023. [DOI] [PubMed] [Google Scholar]
  15. Jarrett W., Jarrett O., Mackey L., Laird H., Hardy W., Jr, Essex M. Horizontal transmission of leukemia virus and leukemia in the cat. J Natl Cancer Inst. 1973 Sep;51(3):833–841. doi: 10.1093/jnci/51.3.833. [DOI] [PubMed] [Google Scholar]
  16. Levin R., Ruscetti S. K., Parks W. P., Scolnick E. M. Expression of feline type-C virus in normal and tumor tissues of the domestic cat. Int J Cancer. 1976 Nov 15;18(5):661–671. doi: 10.1002/ijc.2910180515. [DOI] [PubMed] [Google Scholar]
  17. Livingston D. M., Todaro G. J. Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus. Virology. 1973 May;53(1):142–151. doi: 10.1016/0042-6822(73)90473-x. [DOI] [PubMed] [Google Scholar]
  18. McAllister R. M., Nicolson M., Gardner M. B., Rongey R. W., Rasheed S., Sarma P. S., Huebner R. J., Hatanaka M., Oroszlan S., Gilden R. V. C-type virus released from cultured human rhabdomyosarcoma cells. Nat New Biol. 1972 Jan 5;235(53):3–6. doi: 10.1038/newbio235003a0. [DOI] [PubMed] [Google Scholar]
  19. Neiman P. E. Measurement of RD114 virus nucleotide sequences in feline cellular DNA. Nat New Biol. 1973 Jul 11;244(132):62–64. doi: 10.1038/newbio244062a0. [DOI] [PubMed] [Google Scholar]
  20. Niman H. L., Stephenson J. R., Gardner M. B., Roy-Burman P. RD-114 and feline leukaemia virus genome expression in natural lymphomas of domestic cats. Nature. 1977 Mar 24;266(5600):357–360. doi: 10.1038/266357a0. [DOI] [PubMed] [Google Scholar]
  21. Okabe H., Gilden R. V., Hatanaka M. RD 114 virus-specific sequences in feline cellular RNA: detection and characterization. J Virol. 1973 Nov;12(5):984–994. doi: 10.1128/jvi.12.5.984-994.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Okabe H., Gilden R. V., Hatanaka M. Specificity of the DNA product of RNA-dependent DNA polymerase in type C viruses. II. Quantitative analysis. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3923–3927. doi: 10.1073/pnas.70.12.3923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Okabe H., Twiddy E., Gilden R. V., Hatanaka M., Hoover E. A., Olsen R. G. FeLV-related sequences in DNA from a FeLV-free cat colony. Virology. 1976 Feb;69(2):798–801. doi: 10.1016/0042-6822(76)90510-9. [DOI] [PubMed] [Google Scholar]
  24. Oroszlan S., Bova D., Martin White M. H., Toni R., Foreman C., Gilden R. V. Purification and immunological characterization of the major internal protein of the RD-114 virus. Proc Natl Acad Sci U S A. 1972 May;69(5):1211–1215. doi: 10.1073/pnas.69.5.1211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Quintrell N., Varmus H. E., Bishop J. M., Nicholson M. O., McAllister R. M. Homologies among the nucleotide sequences of the genomes of C-type viruses. Virology. 1974 Apr;58(2):568–575. doi: 10.1016/0042-6822(74)90090-7. [DOI] [PubMed] [Google Scholar]
  26. Rasheed S., Nelson-Rees W. A., Toth E. M., Arnstein P., Gardner M. B. Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer. 1974 Apr;33(4):1027–1033. doi: 10.1002/1097-0142(197404)33:4<1027::aid-cncr2820330419>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  27. Roy-Burman P. Deoxyribonucleic acid polymerase associated with feline leukemia and sarcoma viruses: properties of the enzyme and its product. Int J Cancer. 1971 May 15;7(3):409–415. doi: 10.1002/ijc.2910070306. [DOI] [PubMed] [Google Scholar]
  28. Roy-Burman P., Kaplan M. B. Nucleotide composition of the RNA from RD-114 virions. Biochem Biophys Res Commun. 1972 Sep 26;48(6):1354–1361. doi: 10.1016/0006-291x(72)90861-3. [DOI] [PubMed] [Google Scholar]
  29. Roy-Burman P., Klement V. Derivation of mouse sarcoma virus (Kirsten) by acquisition of genes from heterologous host. J Gen Virol. 1975 Aug;28(2):193–198. doi: 10.1099/0022-1317-28-2-193. [DOI] [PubMed] [Google Scholar]
  30. Sarma P. S., Log T. Subgroup classification of feline leukemia and sarcoma viruses by viral interference and neutralization tests. Virology. 1973 Jul;54(1):160–169. doi: 10.1016/0042-6822(73)90125-6. [DOI] [PubMed] [Google Scholar]
  31. Sarma P. S., Tseng J., Lee Y. K., Gilden R. V. Virus similar to RD114 virus in cat cells. Nat New Biol. 1973 Jul 11;244(132):56–59. doi: 10.1038/newbio244056a0. [DOI] [PubMed] [Google Scholar]
  32. Scolnick E. M., Parks W. P., Livingston D. M. Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol. 1972 Sep;109(3):570–577. [PubMed] [Google Scholar]
  33. Sherr C. J., Fedele L. A., Benveniste R. E., Todaro G. J. Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses. J Virol. 1975 Jun;15(6):1440–1448. doi: 10.1128/jvi.15.6.1440-1448.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Smith R. G., Donehower L., Gallo R. C., Gillespie D. H. Rapid purification of 70S RNA from media of cells producing RNA tumor viruses. J Virol. 1975 Jan;17(1):287–290. doi: 10.1128/jvi.17.1.287-290.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Stephenson J. R., Aaronson S. A. Expression of endogenous RNA C-type virus group-specific antigens in mammalian cells. J Virol. 1973 Sep;12(3):564–569. doi: 10.1128/jvi.12.3.564-569.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Stephenson J. R., Hino S., Garrett E. W., Aaronson S. A. Immunological cross reactivity of Mason-Pfizer monkey virus with type C RNA viruses endogenous to primates. Nature. 1976 Jun 17;261(5561):609–611. doi: 10.1038/261609a0. [DOI] [PubMed] [Google Scholar]
  37. Sutton W. D. A crude nuclease preparation suitable for use in DNA reassociation experiments. Biochim Biophys Acta. 1971 Jul 29;240(4):522–531. doi: 10.1016/0005-2787(71)90709-x. [DOI] [PubMed] [Google Scholar]
  38. Todaro G. J., Benveniste R. E., Callahan R., Lieber M. M., Sherr C. J. Endogenous primate and feline type C viruses. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):1159–1168. doi: 10.1101/sqb.1974.039.01.133. [DOI] [PubMed] [Google Scholar]

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