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. 1977 Sep;23(3):626–636. doi: 10.1128/jvi.23.3.626-636.1977

Genetic and physiological control of host cell lysis by bacteriophage lambda.

B G Rolfe, J H Campbell
PMCID: PMC515874  PMID: 330879

Abstract

The timing of host cell lysis at the end of the lytic cycle of phage lambda is under complex control. The lambda S protein stimulates lysis. Another physiological system, the lysis regulator, inhibitis lysis from occurring prematurely. The effects of a series of phage and bacterial mutations on these controls are described. They show that the lambda rex gene plays a role in regulating lysis under suboptimal growth conditions. In certain mutant cells, and especially under anaerobic culture conditions, the rex gene aids in the scheduling of host cell lysis. The data also suggest that the lysis regulator may control the transition of the lambda S protein from an inactive to an active state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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