Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1977 Sep;23(3):811–815. doi: 10.1128/jvi.23.3.811-815.1977

Correlation of virus polypeptide structure with attenuation of poliovirus type 1.

J B Milstien, J R Walker, L J Eron
PMCID: PMC515892  PMID: 197272

Abstract

Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions.

Full text

PDF
811

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beckman L. D., Caliguiri L. A., Lilly L. S. Cleavage site alterations in poliovirus-specific precursor proteins. Virology. 1976 Aug;73(1):216–227. doi: 10.1016/0042-6822(76)90076-3. [DOI] [PubMed] [Google Scholar]
  2. HOLLAND J. J., McLAREN L. C. Improved method for staining cell monolayers for virus plaque counts. J Bacteriol. 1959 Oct;78:596–597. doi: 10.1128/jb.78.4.596-597.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. LI C. P., SCHAEFFER M. Isolation of a non-neurotropic variant of type I poliomyelitis virus. Proc Soc Exp Biol Med. 1954 Oct;87(1):148–153. doi: 10.3181/00379727-87-21317. [DOI] [PubMed] [Google Scholar]
  4. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  5. Phillips B. A., Fennell R. Polypeptide composition of poliovirions, naturally occurring empty capsids, and 14S precursor particles. J Virol. 1973 Aug;12(2):291–299. doi: 10.1128/jvi.12.2.291-299.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Tattersall P., Cawte P. J., Shatkin A. J., Ward D. C. Three structural polypeptides coded for by minite virus of mice, a parvovirus. J Virol. 1976 Oct;20(1):273–289. doi: 10.1128/jvi.20.1.273-289.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES