Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1977 Nov;24(2):716–719. doi: 10.1128/jvi.24.2.716-719.1977

DNA injection and genetic recombination of alkylated bacteriophage T7 in the presence of nalidixic acid.

B Karska-Wysocki, M D Mamet-Bratley, G Przewlocki
PMCID: PMC515987  PMID: 916036

Abstract

Marker rescue experiments with alkylated T7 bacteriophage carried out in the presence and in the absence of nalidixic acid suggest that the gradient in rescue is due to two alkylation-induced causes: a DNA injection defect and an interference with DNA synthesis.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baird J. P., Bourguignon G. J., Sternglanz R. Effect of nalidixic acid on the growth of deoxyribonucleic acid bacteriophages. J Virol. 1972 Jan;9(1):17–21. doi: 10.1128/jvi.9.1.17-21.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Broker T. R., Doermann A. H. Molecular and genetic recombination of bacteriophage T4. Annu Rev Genet. 1975;9:213–244. doi: 10.1146/annurev.ge.09.120175.001241. [DOI] [PubMed] [Google Scholar]
  3. Doermann A. H. T4 and the rolling circle model of replication. Annu Rev Genet. 1973;7:325–341. doi: 10.1146/annurev.ge.07.120173.001545. [DOI] [PubMed] [Google Scholar]
  4. Dressler D., Wolfson J., Magazin M. Initiation and reinitiation of DNA synthesis during replication of bacteriophage T7. Proc Natl Acad Sci U S A. 1972 Apr;69(4):998–1002. doi: 10.1073/pnas.69.4.998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fidanián H. M., Ray D. S. Replication of bacteriophage M13. 8. Differential effects of rifampicin and nalidixic acid on the synthesis of the two strands of M13 duplex DNA. J Mol Biol. 1974 Feb 15;83(1):63–82. doi: 10.1016/0022-2836(74)90424-0. [DOI] [PubMed] [Google Scholar]
  6. Howard-Flanders P. DNA repair and recombination. Br Med Bull. 1973 Sep;29(3):226–235. doi: 10.1093/oxfordjournals.bmb.a071012. [DOI] [PubMed] [Google Scholar]
  7. Karska-Wysocki B., Mamet-Bratley M. D., Verly W. G. Action of ethyl and methyl methane sulfonates on DNA injection and genetic recombination in T7 bacteriophage. J Virol. 1976 Aug;19(2):318–324. doi: 10.1128/jvi.19.2.318-324.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Karska-Wysocki B., Thibodeau L., Verly W. G. Inactivation of the T7 coliphage by monofunctional alkylating agents. Action of phage adsorption and injection of its DNA. Biochim Biophys Acta. 1976 Jun 18;435(2):184–191. doi: 10.1016/0005-2787(76)90249-5. [DOI] [PubMed] [Google Scholar]
  9. Kerr C., Sadowski P. D. The involvement of genes 3,4,5 and 6 in genetic recombination in bacteriophage T7. Virology. 1975 May;65(1):281–285. doi: 10.1016/0042-6822(75)90031-8. [DOI] [PubMed] [Google Scholar]
  10. Kozinski A. W., Doermann A. H., Kozinski P. B. Absence of interparental recombination in multiplicity reconstitution from incomplete bacteriophage T4 genomes. J Virol. 1976 Jun;18(3):873–884. doi: 10.1128/jvi.18.3.873-884.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Krisch R. E. Lethal and genetic effects of radiophosphorus decay in bacteriophages SP82G and T7. Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Mar;25(3):261–276. doi: 10.1080/09553007414550321. [DOI] [PubMed] [Google Scholar]
  12. Levy J. N. Effects of radiophosphorus decay in bacteriophage T4D. II. The mechanism of marker rescue. Virology. 1975 Nov;68(1):14–26. doi: 10.1016/0042-6822(75)90143-9. [DOI] [PubMed] [Google Scholar]
  13. Pao C. C., Speyer J. F. Order of injection of T7 bacteriophage DNA. J Virol. 1973 Jun;11(6):1024–1026. doi: 10.1128/jvi.11.6.1024-1026.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Simon M. N., Studier F. W. Physical mapping of the early region of bacteriophage T7 DNA. J Mol Biol. 1973 Sep 15;79(2):249–265. doi: 10.1016/0022-2836(73)90004-1. [DOI] [PubMed] [Google Scholar]
  15. Studier F. W. The genetics and physiology of bacteriophage T7. Virology. 1969 Nov;39(3):562–574. doi: 10.1016/0042-6822(69)90104-4. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES