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. 2016 Nov 23;14:148–160. doi: 10.1016/j.ebiom.2016.11.027

Fig. 6.

Fig. 6

LFES primarily inhibits neurons in the ventral hippocampal CA3 by activating entorhinal CaMKIIα-positive neurons. a–b) Representative peri-event rasters showing the responses of PNs and INs in the ventral hippocampal CA3 area during LFES or photo-stimulation (473 nm, 1 Hz) in the EC; a: LFES in WT mice (n = 10); and b: photo-stimulation in CaMKIIα-ChR2EC mice (n = 8). c) Distribution of hippocampal INs and PNs according to their response to entorhinal LFES or photo-stimulation (1 Hz) (χ2 test). d) Representative peri-event rasters and population data indicated that blue light stimulation at LMol modulated hippocampal neurons in CaMKIIα-ChR2EC mice (n = 6). e) Entorhinal photo-stimulation (593 nm, 20 Hz) attenuated the inhibitory effect of entorhinal LFES in CaMKIIα-eNPHR3.0EC mice (paired t-test). f) Entorhinal photo-stimulation (593 nm, 20 Hz) increased spiking frequency in hippocampal PNs (left) but not INs (right) in CaMKIIα-eNPHR3.0EC mice (paired t-test). Data are displayed as mean ± SEM. **p < 0.01, ***p < 0.001 compared to PRI or baseline.