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. 1991 Jun 1;88(11):4570–4571. doi: 10.1073/pnas.88.11.4570

The MCK enhancer contains a p53 responsive element.

H Weintraub 1, S Hauschka 1, S J Tapscott 1
PMCID: PMC51706  PMID: 1647009

Abstract

p53 is an antioncogene that is defective or absent in a large number of human tumors. Its function in normal cells is not known. We show that co-transfection of mouse p53 with muscle-specific creatine kinase-chloramphenicol acetyltransferase reporter gene, containing 3.3 kilobase of upstream control sequence for the muscle-specific creatine kinase gene, results in a 10- to 80-fold activation. The p53 responsive element maps to a region distinguished from the known MyoD binding region. Identification of a p53 responsive element should allow a more focused analysis of the effects of p53 in controlling gene activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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