Table 1. Clinicopathologic correlation of GLK protein levels in NSCLC patients.
| Subject characteristics | n (%) Median† | GLK-Low (n = 33) | GLK-High (n = 25) | P‡ |
|---|---|---|---|---|
| Age (years) | 65.0 (11.3) | |||
| < 60 | 18 (31.0) | 8 | 10 | 0.256 |
| ≥ 60 | 40 (69.0) | 25 | 15 | |
| Gender | ||||
| Male | 35 (60.3) | 16 | 19 | 0.569 |
| Female | 23 (39.7) | 17 | 6 | |
| Surgical procedure | ||||
| Limited | 6 (10.3) | 5 | 1 | 0.349 |
| Lobectomy | 49 (84.5) | 27 | 22 | |
| Pneumonectomy | 3 (5.2) | 1 | 2 | |
| Histologic grade | ||||
| Well | 5 (8.6) | 5 | 0 | 0.143 |
| Moderate | 27 (46.6) | 14 | 13 | |
| Poor | 26 (44.8) | 14 | 12 | |
| Tumor type | ||||
| SCC | 21 (36.2) | 10 | 10 | 0.578 |
| AC | 37 (63.8) | 23 | 15 | |
| Pathologic stage | ||||
| I + II | 44 (75.9) | 26 | 18 | 0.758 |
| III | 14 (24.1) | 7 | 7 | |
| T-stage | ||||
| T1 | 8 (13.8) | 5 | 3 | 1.000 |
| T2 | 34 (58.6) | 19 | 15 | |
| T3 + T4 | 16 (27.6) | 9 | 7 | |
| N-stage | ||||
| N0 | 39 (67.2) | 22 | 17 | 1.000 |
| N1+N2 | 19 (32.8) | 11 | 8 | |
| M-stage | ||||
| M0 | 57 (98.3) | 33 | 24 | 0.247 |
| M1 | 1 (1.7) | 0 | 1 | |
| Smoking status | ||||
| Nonsmoker | 27 (46.6) | 18 | 9 | 0.207 |
| Current smoker | 14 (24.1) | 5 | 9 | |
| Former smoker | 17 (29.3) | 10 | 7 | |
| Alcohol status | ||||
| No | 49 (84.5) | 30 | 19 | 0.154 |
| Yes | 9 (15.5) | 3 | 6 | |
| Recurrence | ||||
| No | 34 (58.6) | 24 | 10 | 0.012* |
| Yes | 24 (41.4) | 9 | 15§ |
Abbreviations: NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma; AC, adenocarcinoma
*
P-value < 0.05, statistical significance
†
Categorical data: n (%); Continuous variables: Mean (SD)
‡
P values were calculated with the use of the Fisher's Exact Test
§
Relative risk, 2.20, 95% CI, 1.157–4.183