Table 1. PDGFR-α and PDGFR-β as prognostic factors for overall survival in multivariate analyses in patients with mCRC (NORDIC-VII cohort; n=311).
| Adjusted with PDGFR-α | Adjusted with PDGFR-β | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P value | HR (95% CI) | P value |
| PDGFR-α (low vs. high) | 1.44 (1.09-1.91) |
0.011 | - | - |
| PDGFR-β (low vs. high) | - | - | 1.82 (1.09-3.04) |
0.023 |
| Alkaline Phosphatase (elevated vs. normal) | 2.00 (1.50-2.69) |
<0.001 | 1.98 (1.47-2.65) |
<0.001 |
| Performance status (1 vs. 0) | 1.92 (1.41-2.60) |
<0.001 | 1.90 (1.40-2.57) |
<0.001 |
| Performance status (2 vs. 0) | 4.02 (2.18-7.43) |
<0.001 | 3.66 (1.99-6.73) |
<0.001 |
| BRAF (mut vs. wt) | 2.94 (1.91-4.29) |
<0.001 | 2.94 (1.09-3.04) |
<0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; mut, mutant; wt, wild type.