Table 1. Summary of genome-wide association study results of 4 SNPs at 6p21.3 independently associated with CIN3.

					MAF		Single SNPc		Stepwise conditional analysis
Loci	SNP	Positiona	Nearby gene	Allelesb	Case	Control	OR (95%CI)	P	OR (95%CI)	P
1	rs9271898	32595972 (class I)	HLA-DRB1, HLA-DQA1	G > A	0.38	0.49	0.64(0.59–0.70)	1.2×10−24	–	–
2	rs2516448	31390410 (class I)	MICA	C > T	0.58	0.50	1.39(1.28–1.52)	1.1×10−15	1.41(1.30–1.54)d	5.6 × 10−16 d
3	rs3130196	33063219 (class II)	HLA-DPB1, HLA-DPA1	T > C	0.17	0.13	1.40(1.26–1.57)	2.3×10−9	1.40(1.25–1.57)e	9.4 × 10−9 e
4	rs115625939	32583584 (class II)	HLA-DRB1, HLA-DQA1	A > G	0.09	0.15	0.58(0.51–0.67)	1.4×10−15	0.68(0.58–0.79)f	3.2 × 10−7f

MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; P, two-sided P value corresponding to the OR.

^aGRCh37/hg19 Assembly.

^bMajor allele > Minor allele

^cORs and 95%CIs for minor allele in log-additive model were derived from logistic regression with adjustment for study and one significant principal component generated by principal components analysis.

^dConditioning on rs9271898.

^eConditioning on rs9271898 and rs2516448

^fConditioning on rs9271898, rs2516448 and rs3130196.