There is an error in Table 3. The values in columns Post-prime, Post-boost and Post-challenge were incorrectly omitted. The authors have provided a corrected version here. The publisher apologizes for the error.
Table 3. Reciprocal titres of anti-FMDV antibodies (serotype O) in sera from calves in experiment 3.
| Post-prime | Post-boost | Post-challenge | |||
|---|---|---|---|---|---|
| Group | Vaccination | Animal | PVD 14 | PVD 28 | PVD 36 |
| 1 | No vaccination (control) | C1 | - | - | 40 |
| C2 | - | - | 40 | ||
| C3 | - | - | 160 | ||
| 2 | rSFV-FMDV-P1-2A-mIRES-3C (PVD 0) + empty capsid particles (PVD 14) | C4 | - | 320 | 1280 |
| C5 | - | 40 | 320 | ||
| C6 | 20 | 320 | 1280 | ||
| 3 | empty capsid particles (PVD 0) + rSFV-FMDV-P1-2A-mIRES-3C (PVD 14) | C7 | 20 | 20 | 5120 |
| C8 | - | 80 | 5120 | ||
| C9 | - | 10 | 5120 |
Calves were either unvaccinated (group 1) or vaccinated with rSFV-FMDV-P1-2A-mIRES-3C (on PVD 0) followed by empty capsid particles (on PVD 14) (group 2) or vaccinated with empty capsids on PVD 0 and then with rSFV-FMDV-P1-2A-mIRES-3C on PVD 14 (group 3). All cattle were challenged with FMDV by needle inoculation on PVD 28. Sera collected on PVD 14, 28 (pre-challenge) and 36 were titred in the blocking ELISA using 2-fold dilutions starting at 1:5.—indicates negative.
Reference
- 1.Gullberg M, Lohse L, Bøtner A, McInerney GM, Burman A, Jackson T, et al. (2016) A Prime-Boost Vaccination Strategy in Cattle to Prevent Foot-and-Mouth Disease Using a “Single-Cycle” Alphavirus Vector and Empty Capsid Particles. PLoS ONE 11(6): e0157435 doi:10.1371/journal.pone.0157435 [DOI] [PMC free article] [PubMed] [Google Scholar]