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. 2016 Oct 18;95(1):18–26. doi: 10.2471/BLT.15.167726

The economic burden of dementia in China, 1990–2030: implications for health policy

Charge économique de la démence en Chine de 1990 à 2030: conséquences sur la politique sanitaire

La carga económica de la demencia en China, 1990–2030: implicaciones para la política sanitaria

العبء الاقتصادي للخَرَف في الصين في الفترة ما بين عامي 1990 و2030: الآثار المترتبة على السياسة الصحية

1990 年至 2030 中国境内痴呆症的经济负担： 对卫生政策的影响

Экономическое бремя деменции в Китае, 1990–2030 гг. Последствия для политики в области здравоохранения

Junfang Xu a, Jian Wang b, Anders Wimo c, Laura Fratiglioni d, Chengxuan Qiu d,✉
PMCID: PMC5180346  PMID: 28053361

Abstract

Objective

To quantify and predict the economic burden of dementia in China for the periods 1990–2010 and 2020–2030, respectively, and discuss the potential implications for national public health policy.

Methods

Using a societal, prevalence-based, gross cost-of-illness approach and data from multiple sources, we estimated or predicted total annual economic costs of dementia in China. We included direct medical costs in outpatient and inpatient settings, direct non-medical costs – e.g. the costs of transportation – and indirect costs due to loss of productivity. We excluded comorbidity-related costs.

Findings

The estimated total annual costs of dementia in China increased from 0.9 billion United States dollars (US$) in 1990 to US$ 47.2 billion in 2010 and were predicted to reach US$ 69.0 billion in 2020 and US$ 114.2 billion in 2030. The costs of informal care accounted for 94.4%, 92.9% and 81.3% of the total estimated costs in 1990, 2000 and 2010, respectively. In China, population ageing and the increasing prevalence of dementia were the main drivers for the increasing predicted costs of dementia between 2010 and 2020, and population ageing was the major factor contributing to the growth of dementia costs between 2020 and 2030.

Conclusion

In China, demographic and epidemiological transitions have driven the growth observed in the economic costs of dementia since the 1990s. If the future costs of dementia are to be reduced, China needs a nationwide dementia action plan to develop an integrated health and social care system and to promote primary and secondary prevention.

Introduction

According to the 2013 Alzheimer’s Disease International report, about 44.4 million people were living with dementia in 2013 and this number is expected to reach an estimated 75.6 million by 2030.1 In China, which has the largest population of people with dementia, the prevalence of dementia appears to have increased steadily between 1990 and 2010.2,3 However, this trend might be partly attributed to temporal variations in the methods used to estimate such prevalence.4 The results of a national survey in 2008–2009 indicated that dementia was more common in rural areas than in urban settings.5 Given the rapid growth of the elderly population in China,6 dementia is expected to pose tremendous challenges to the national health-care system and to the sustainable development of the national economy.

Most cost-of-illness studies for dementia have been carried out in high-income countries such as Sweden, the United Kingdom of Great Britain and Northern Ireland and the United States of America.7–11 The economic costs of dementia in China – which have yet to be investigated in detail – are likely to differ, both in magnitude and type, from those in such distant high-income countries.

In this study, we sought to estimate and predict the costs of dementia in China for the periods 1990–2010 and 2020–2030, respectively. It was hoped that, by quantifying the economic costs of dementia, Chinese policy-makers would be motivated to develop a nationwide action plan, prioritize policies on dementia-related care and research and reduce the economic and societal burdens of dementia in China.

Methods

In this cost-of-illness study, we used a prevalence-based, bottom-up approach to quantify or predict the costs of dementia in China between 1990 and 2030, from a societal perspective. We categorized all the costs into three classes:12,13 (i) direct medical costs, that is goods and service costs related to the diagnosis and treatment of inpatients and outpatients with dementia; (ii) direct non-medical costs, that is transport costs and costs related to formal care in nursing homes or informal care at home; and (iii) indirect costs resulting from dementia-attributable loss of productivity.

Data sources

We used multiple data sources for all estimates. We used age-specific prevalence of dementia in China, for the period 1990–2010, derived from a comprehensive systematic review.3 From the electronic health records of the facilities, we collected cost data for patients with diagnosed dementia who were admitted either to the Shandong Centre for Mental Health – the only provincial psychiatric hospital in the eastern province of Shandong – between 1 January 2005 and 31 March 2014 or to the Daizhuang Psychiatric Hospital – one of the oldest psychiatric hospitals in China and also in Shandong province – between 1 January 2012 and 30 September 2014. The routine electronic health records include sociodemographic data and data on clinical diagnosis and disease classification, itemized costs, e.g. for drugs, examinations and beds. In each of the two study facilities, dementia was diagnosed and defined according to the International statistical classification of diseases and related health problems, 10th revision.14 We excluded 26 patients with dementia who were diagnosed as having other chronic conditions that needed treatment, e.g. anxiety, diabetes or hypertension, leaving data from the records of 146 patients with dementia in our analysis. We also searched the China National Knowledge Infrastructure, PubMed and Wanfang bibliographic databases for studies, on the use of health resource by people with dementia in China, published between 1 January 1990 and 31 July 2015. The search terms included “Alzheimer’s disease”, “China”, “cost burden”, “dementia”, “economic burden”, “formal care” and “informal care”. We obtained costs for outpatient visits and transportation from a published study.15 Data on demographics and wages came from the China Statistical Yearbook 2015.16 The United Nations population projections for China17 and predictions of the prevalence of dementia based on data from a systematic review3 were used to estimate the total numbers of people in China who would have dementia in 2020 and 2030.

Cost estimates

For our estimates we included costs for hospitalization, formal care, informal care, loss of productivity, outpatient care and transportation. Our estimates of hospitalization costs, which included the costs of all medicines, clinical examinations, specialist consultations and bed care, were based on the mean values of the costs recorded in the electronic health records of the two study facilities and the values given in a published article15 – all weighted according to the sample sizes. Our estimates of the costs of formal care were similarly weighted mean values based on published data.18,19 Informal care costs were estimated assuming that a carer, who might otherwise be earning the national mean salary,13 spent a mean of 6.3 hours per day20 giving care to each dementia case in informal care at home. We assumed that, during the observational periods, 86% of Chinese dementia cases were receiving informal care at home and that 4.9% of such cases would seek formal care.13,21 We estimated the numbers of disability-adjusted life-years (DALYs) lost because of dementia using each case’s dementia severity score, assessed using the Global Deterioration Scale,22 and different weights for each of seven levels of severity.23 Costs of the productivity lost because of dementia-related disability were then estimated. For these estimations, we assumed that each person aged at least 60 years had a mean productivity weight of 0.1 and we used an annual discount rate of 3.5% to adjust the costs to 2015 values.24 Outpatient care costs included the costs of treatments and specialist consultations received in clinics or at home.15 Transportation costs comprised the costs travelling to and from medical centres.15

All the estimated costs were converted to United States dollar (US$) values in January 2015, when US$ 1 was equivalent to about 6.2 Chinese yuan.

Statistical analysis

We estimated the numbers of people with dementia in China in 1990, 2000 and 2010 by multiplying the age-specific prevalence of dementia3 by the corresponding numbers of people in each age group in the population. For our predictions for 2020 and 2030, we used age-specific prevalence derived using a regression model and the relevant data from a comprehensive review.3 We estimated the total annual costs of dementia by multiplying the mean costs per patient by the total number of patients with dementia. Total annual costs for 2020 and 2030 were projected using a dynamic general disequilibrium model25 and assuming that the use of health resources by a dementia case was constant while the elderly population grew and the age-specific prevalence of dementia varied over time. We employed the Laspeyres decomposition method to estimate the relative contributions made by the ageing population and changes in the age-specific prevalence of dementia to the predicted future costs of dementia.26 When the relevant data on medical costs for particular years were missing, we assumed that those costs would have increased by the same amount as the per-capita gross domestic product (GDP).

We conducted multiple sensitivity analyses to assess the impact of variations in the key input parameters on our primary estimates. Specifically, we estimated the total costs of dementia by (i) using prevalence data derived from a different systematic review2 that yielded more conservative estimates of the prevalence of dementia than those that we used3 for our primary estimates; (ii) assuming that medical costs would increase 5% every year; (iii) using the minimum and maximum values – instead of the overall mean – for the hours spent on informal care;27 (iv) using the means of the minimum and maximum values recorded, in China’s 22 provinces, five autonomous regions and four municipalities, for an informal carer’s wages – instead of the overall national mean value; (v) assuming that dementia cases aged at least 60 years had a mean productivity weight of 0.5027 instead of 0.1; (vi) assuming that 70% or 99% of people with dementia – instead of 86% – would live at home;7 and (vii) assuming that 60.4% or 0.4% of dementia patients – instead of 4.9% – would seek professional care.21

Results

The total number of people with dementia in China was estimated to be about 3.5 million in 1990, 5.1 million in 2000 and 9.6 million in 2010 (Table 1). The overall prevalence of dementia among people aged at least 60 years was projected to increase from 5.8% in 2020 to 6.7% in 2030 (Table 2). The total number of people with dementia in China was projected to reach 14.1 million by 2020 and 23.3 million by 2030.

Table 1. Estimated numbers of people with dementia, China, 1990, 2000 and 2010.

Variable Thousands of people with dementiaa
1990 n = 2479.7 2000 n = 5148.4 2010 n = 9615.6
Age in years
60–64 314.3 454.6 792.0
65–69 462.0 726.9 1060.7
70–74 654.7 989.7 1569.5
75–79 726.1 1099.1 2027.4
80–84 655.0 948.3 1956.5
85–89 435.7 598.3 1369.7
≥ 90 231.9 331.6 839.7
Sex
Male 1313.1 1942.8 3628.5
Female 2166.6 3205.6 5987.1
Residence
Urban 2109.8 3121.5 5829.9
Rural 1370.0 2026.9 3785.7
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NOTE: Inconsistencies arise in some values due to rounding.

a Estimates based on a systematic review of the prevalence of dementia in China.3

Table 2. Predicted age-specific prevalence of dementia and numbers of people with dementia, China, 2020 and 2030.

Age in years 2020
 2030
Prevalence (%) Thousands of cases Prevalence (%) Thousands of cases
60–64 1.5 1 121.1 1.7 1 879.0
65–69 3.0 2 117.3 3.4 2 966.8
70–74 5.3 2 340.7 6.0 3 661.7
75–79 9.7 2 593.2 11.0 5 477.5
80–84 16.6 2 717.8 18.8 4 547.9
85–89 27.8 2 096.8 31.5 2 997.0
≥ 90 47.4 1 082.1 53.9 1 760.8
≥ 60a 5.8 14 069.0 6.7 23 290.7
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a The values shown cover all of the expected dementia cases aged at least 60 years.

Between 1990 and 2010, the mean annual costs of formal and informal care for each dementia case increased more than 60-fold and more than 18-fold, respectively (Table 3). Over the same period, the national total annual costs of dementia increased more than 50-fold, from about US$ 0.9 billion in 1990 to approximately US$ 47.2 billion, or about 0.7% of China’s GDP in 2010.

Table 3. Estimated costs of dementia, China, 1990, 2000 and 2010.

Cost item Year
1990 2000 2010
Costs per case (US$)
Direct medical costs
    Hospitalization cost 37.1 370.0 1 004.0
    Outpatient care cost 0.5 5.0 148.8
Direct non-medical costs
    Nursing home care 47.4 222.4 4 468.1
    Transportation 0.5 4.9 143.8
    Informal care 271.5 1184.0 4 635.4
Indirect costs
    Cost due to DALYs lost 4.8 22.9 87.6
Total for cases living at home 314.4 1 586.8 6 019.6
Total for cases living in nursing homes 90.3 625.2 5 852.3
National costs (US$ millions)
Direct medical costs
    Hospitalization cost 6.3 93.3 473.0
    Outpatient care cost 1.8 26.1 1 431.0
Direct non-medical costs
    Nursing home care 23.1 160.3 6 014.9
    Transportation 0.1 1.2 67.8
    Informal care 812.4 5 242.3 38 332.0
Indirect costs
    Cost due to DALYs lost 16.7 118.1 842.3
Total for all cases 860.4 5 641.4 47 161.0
Sex of case
    Men 324.7 2 128.6 17 796.5
    Women 535.7 3 512.2 29 364.2
Residence of case
    Urban 514.6 3 375.0 28 578.9
    Rural 345.8 2 266.4 18 582.1
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DALYs: disability-adjusted life-years; US$: United States dollars.

Note: All the estimated costs were converted to United States dollar (US$) values in January 2015, when US$ 1 was equivalent to about 6.2 Chinese yuan.

The total costs of dementia were projected to reach US$ 69.0 billion in 2020 and US$ 114.2 billion in 2030 (Fig. 1). The ageing population and increases in dementia prevalence appeared to be the major driving factors for the high costs of dementia in 2010–2020 and the ageing population also appeared to be the dominant force behind the growth of dementia costs between 2020 and 2030 (Fig. 2).

Fig. 1.

Estimated total annual costs of dementia, China, 1990–2030

US$: United States dollars.

Note: All the estimated costs were converted to United States dollar (US$) values in January 2015 – when US$ 1 was equivalent to about 6.2 Chinese yuan.

Fig. 1

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Fig. 2.

Attribution of the causes of the changes in total annual costs of dementia care, China, 2010–2030

US$: United States dollars.

Note: All the estimated costs were converted to United States dollar (US$) values in January 2015 – when US$ 1 was equivalent to about 6.2 Chinese yuan.

Fig. 2

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According to our estimates, the costs of informal care for dementia accounted for 94.4%, the total costs of dementia care in China in 1990, decreasing to 92.9% in 2000 and 81.3% in 2010 (Fig. 3). In contrast, the costs of formal care accounted for just 2.7% of the total costs in 1990, increasing to 2.8% in 2000 and 12.8% in 2010. Hospitalization costs accounted for only about 1% of total costs in each year between 1990 and 2010.

Fig. 3.

Relative contributions made by six cost items to the total annual costs of dementia care, China, 1990, 2000 and 2010

DALYs: disability-adjusted life-years.

Fig. 3

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The results of our sensitivity analyses indicated that variations in informal care hours, prevalence of dementia and productivity weighting had a substantial impact on estimates of the total costs of dementia, whereas changes in medical prices, wages and the proportions of patients living at home or seeking professional care had relatively little impact on such estimates (Table 4).

Table 4. Changes in the estimated annual costs of dementia according to variations in the key parameters considered in sensitivity analyses, China, 1990, 2000, 2010, 2020 and 2030.

Parameter varied Changes in estimated total costs,a US$ billions (%)
1990 2000 2010 2020 2030
Prevalence of dementiab −0.5 (−62.3) −1.6 (−27.8) −15.8 (−33.5) −25.0 (−27.6) −34.6 (−23.1)
Medical costs
5% annual increase between 2010 and 2030, instead of 0% ND ND ND +7.3 (+9.6) +31.7 (+21.7)
Informal care in hours per day
2.5 instead of 6.3 −0.5 (−56.9) −3.2 (−56.0) −23.1 (−49.0) −33.8 (−49.0) −56.0 (−49.0)
8.9 instead of 6.3 +0.3 (+39.0) +2.2 (+38.4) +15.8 (+33.5) +23.1 (+33.5) +38.3 (+33.5)
Wage for caregiversc
Minimum instead of mean ND −1.2 (−21.4) −9.3 (−19.8) −13.7 (−19.8) −22.6 (−19.8)
Maximum instead of mean ND +2.1 (+37.6) +5.5 (+11.7) +8.1 (+11.7) +13.4 (+11.7)
Productivity weight for those aged ≥ 60 years
0.5 instead of 0.1 +0.2 (+27.2) +1.5 (+27.5) +11.2 (+23.8) +16.4 (+23.8) +27.2 (+23.8)
Percentage of cases living at home
70% instead of 86% −0.1 (−14.5) −0.8 (−14.0) −0.3 (−0.5) −0.4 (−0.5) −0.6 (−0.5)
99% instead of 86% +0.1 (+11.8) +0.6 (+11.4) +0.2 (+0.4) +0.3 (+0.4) +0.5 (+0.4)
Percentage of cases seeking professional treatment
60.4% instead of 4.9% +0.1 (+8.5) +1.1 (+19.0) +6.1 (+13.0) +9.0 (+13.0) +14.8 (+13.0)
0.4% instead of 4.9% +0.01 (+0.6) +0.1 (+1.5) +0.5 (+1.1) +0.7 (+1.1) +1.2 (+1.1)
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ND: not determined; US$: United States dollars.

a Compared with the primary estimates of costs.

b Prevalence values given in one systematic review,2 that is, 1.3% in 1990, 2.9% in 2000 and 3.6% in 2010, instead of the values used for the primary estimates, that is, 4.9% in 1990, 5.4% in 2000 and 7.5% in 2010.3

c We used the national mean of the minimum per-capita wages recorded in China’s 22 provinces, five autonomous regions and four municipalities, that is, US$ 1006.6 in 2000 and US$ 3872.6 in 2010, or the national mean of the corresponding maximum wages, that is, US$ 1812.6 in 2000 and US$ 5774.4 in 2010, instead of the overall national mean wages of US$ 1505.3 in 2000 and US$ 5893.4 in 2010. We predicted the corresponding values for 2020 and 2030 from the values for 2010.

Note: All the estimated costs were converted to United States dollar (US$) values in January 2015, when US$ 1 was equivalent to about 6.2 Chinese yuan

Discussion

Increasing costs of dementia

In China, from an age of 60 years, the prevalence of dementia almost doubles every five years and, as elsewhere,28,29 about half of those who have survived to an age of at least 90 years are affected by dementia. According to our estimates, the economic burden of dementia in China will increase substantially over the next few decades and this increase will be driven primarily by population ageing and the increasing prevalence of dementia. Our estimates of the total costs of dementia in China for 2010 and 2030 represent about 7.8% of the estimated US$ 604 billion global cost in 2010 and 10% of the forecasted US$ 1110 billion global cost in 2030.1,7 Our primary estimates of dementia costs are probably underestimates as they ignore the effects, on the costs of care, of home visits by professional careers, the predicted increases in the prevalence of diabetes, hypertension and other risk factors for dementia30 and the predicted increases in the use of medical services and devices.

Our analyses indicated that, in China, informal care accounted for more than 80% of the total dementia costs in 2010. This proportion is consistent with the global trend revealed by a systematic review31 but higher than the proportion, of about 60%, reported for low- and middle-income countries by the World Health Organization.32 In China, the care of an elderly family member is traditionally perceived as an act of filial piety and dementia cases are therefore generally kept out of nursing homes.15,33 In rural areas there is also a lack of facilities and professional carers for dementia cases.34 There is no consensus on how to estimate the costs of informal care – with regard to care hours, costs per hour or types of caregiver – or the potential indirect costs, e.g. of lost productivity, incurred by informal caregivers.7,13,20 As in previous estimates of the global costs of dementia,7,13 we assumed that informal caregivers would be earning the national mean wage if they were not caring for dementia cases. Our estimates of the costs for hospitalization due to dementia indicated that such costs increased more slowly between 2000 and 2010 than between 1990 and 2000. It seems likely that hospitalization costs became more stable in 2003, when the Chinese government launched a programme of health-care reform designed to make medical treatment more accessible.35 Our data also revealed a substantial increase in the proportion of the total costs of dementia care attributed to formal care between 2000 and 2010. In countries with rapid economic growth, the responsiveness of the quantity demanded for a service to a change in the income of the people demanding that service, that is, the income elasticity of demand, usually increases the use of formal care. Given the Chinese tradition of home care and the debate over whether formal care can ever meet all of the emotional and psychological needs of dementia cases,36,37 it remains to be seen whether increasing wealth in China will have much effect on the uptake of formal care for dementia cases. However, it seems possible that China’s one-child policy, which was implemented in the late 1970s and only phased out from 2015, will leave too few adults in the 2030s to give sustainable informal care to all of the dementia cases.38,39

Implications for health policy

In China, public health policy needs to be tailored to address the economic burden posed by dementia. There needs to be greater focus on developing an integrated health and social-care system, including improvements in the efficiency of dementia care and improved health education and financial and social support for dementia cases and their caregivers. Dementia care might be integrated with the national programme for critical illness insurance. Informal caregivers could be taught knowledge and skills relevant to dementia care.40 Central or local governments could adopt preferential tax policies or offer other financial incentives to encourage nongovernmental organizations to participate more in dementia-related care services and education.

Policy-makers also need to establish a strategic action plan designed to promote the primary and secondary prevention of dementia. In the past few decades, epidemiological studies have identified several modifiable risk factors for dementia, e.g. cardiovascular disease, that can be targeted for primary prevention.41 Current intervention strategies against cardiovascular disease are likely to be effective in delaying dementia onset. The declining incidence of dementia in some high-income countries may be attributable to improvements in the control of other risk factors such as diabetes, hypertension and smoking.42–45 In addition, in settings where effective medical and social-care interventions are available, screening for the early detection of dementia may be cost–effective.46,47 Geriatricians in clinical settings should be alert to the first symptoms and signs of the dementia syndrome. Early interventions for dementia may delay entry into nursing homes and reduce the overall costs of care.48

Strengths and limitations

Our estimates were based on data from multiple sources. The cost data on the use of health resources by dementia cases were from itemized routine hospital records, prevalence data were from a comprehensive systematic review3 and United Nations population projections and data from the National Bureau of Statistics of China represented the most authoritative sources for demographic and income data. Our study had several limitations. First, given the considerable variations in economy, cultures, health-care systems, social welfare and traditions across China, cost data from two health facilities in Shandong province are unlikely to be nationally representative. We partly addressed this concern by weighting our estimates and performing multiple sensitivity analyses. The values for income per capita, health expenditure and hospital costs for Shandong province are similar to the mean national values.49 Second, the growth rate of medical prices is generally faster than that of the GDP values we used to fill gaps in the data on dementia costs. Given the increasing awareness and use of health services for dementia, it also seems likely that the costs of medical services will increase more rapidly in the coming decades than by 5% annually, that is, by the rate we used in our sensitivity analysis. Third, as people with dementia often suffer from other chronic health conditions,50,51 comorbidities might reduce the accuracy of our estimates of dementia costs. Fourth, data on the proportion of patients with dementia seeking professional care were very limited. Finally, while we used a dynamic model in our projection to account for the ageing population and changes in prevalence of dementia over time, alterations in other factors – e.g. use of medical devices, prevalence of risk factors for dementia and the hiring of professional caregivers – may have reduced the accuracy of our predictions. If, in the future, additional data become available, alternative approaches such as micro-simulation may provide better cost estimates.52,53

In conclusion, demographic and epidemiological transitions in the past two decades have driven substantial growth in the economic costs of dementia in China. This trend is likely to continue over the next two decades. Given the huge economic burden of dementia, policy-makers in China are advised to make dementia a national health priority and to develop a strategic nationwide action plan. Failure to take appropriate action now will allow the economic burden of dementia to grow even further and could, in the long-term, cause dysfunction throughout China’s entire health-care system.

Acknowledgements

We thank the staff of the two study facilities.

Funding:

This work was supported in part by grants from the National Natural Science Foundation of China (project 71373146), the Independent Innovation Foundation of Shandong University in China (project 2012JC038), and the Swedish Brain Power network. JX was supported by the Sino-Foreign Co-culture Programme of Shandong University for her training, as a visiting doctoral student, at the Karolinska Institutet. CQ received grants from the Swedish Research Council (grant 2015–2531), the Swedish Research Council for Health, Working Life and Welfare (grant 2014–1382) and the Karolinska Institutet.

Competing interests:

AW received grants and personal fees from Eli-Lilly, grants from Nutricia, Ingenix and Envivo and personal fees from Lundbeck. AW owns the copyright on the Resource Use in Dementia instrument, for which he receives royalties.

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