Table 1.
A1AR | Mouse A2AAR |
A3AR | A1AR | Human A2AAR |
A3AR | |
---|---|---|---|---|---|---|
Agonists | ||||||
IB-MECAa,b | 5.9 | ~1000 | 0.087 | 51 | 2900 | 1.8 |
Cl-IB-MECAa,b | 35 | ~10,000 | 0.18 | 220 | 5400 | 1.4 |
MRS5474c,d | 3.20±0.05 | 34±9% | 1056±251 | 50 | 3950 | 470 |
MRS5698e,e | 14% | 27% | 3.1 | 6% | 41% | 3.5 |
MRS5841f,f | 15% | 1% | 11 | 16% | 7% | 1.9 |
MRS5980g,g | 38% | 7% | 36 | 6% | 24% | 0.70 |
CCPAh,i | 0.27 | 988 | 16 | 0.83 | 2270 | 43 |
CPAc,i | 0.22±0.01 | 808±89 | 534±14 | 2.3 | 794 | 43 |
CHAc,j | 2.15±0.37 | 1695±60 | 611±12 | 2.4 | 1390 | 73 |
SPAc,c | 1.08±0.04 | 33±2% | 3111±183 | 7.92±1.55 | 3778±890 | 246±21 |
Cl-ENBAc,k | 0.20±0.01 | 3985±358 | 2414±325 | 0.51 | 1340 | 1290 |
CGS21680c,i | 193±38 | 10±2 | 48±11 | 289 | 27 | 67 |
Antagonists | ||||||
MRS1523n,l | 5,330 | 0% | 702 | >10,000 | 3660 | 19 |
MRS1191c,l | 0% | 0% | 32±3% | >10,000 | >10,000 | 31 |
SCH442416c,m | 765±36 | 1.27±0.04 | 6±2% | 35% | 4.1 | 67% |
DPCPXn,i | 1.5 | 598 | 0% | 3.9 | 129 | 3960 |
Bold indicates a Ki ≥100-fold lower than the other two receptors of the same species. Superscripts indicate the references for literature data (mouse, human). SEMs are included for experimental results.
current results