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. 1948 Apr;55(4):555–559. doi: 10.1128/jb.55.4.555-559.1948
The Effect of Penicillin on the Growth of Mycobacterium tuberculosis in Dubos' Medium 1
Morris Solotorovsky
a, Elizabeth J Bugie
a, Bettina M Frost
a
Morris Solotorovsky
aMerck Institute for Therapeutic Research, Rahway, New Jersey
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Elizabeth J Bugie
aMerck Institute for Therapeutic Research, Rahway, New Jersey
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Bettina M Frost
aMerck Institute for Therapeutic Research, Rahway, New Jersey
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aMerck Institute for Therapeutic Research, Rahway, New Jersey
1
A preliminary report of this study was presented before the Theobald Smith Society on June 21, 1947. Kirby and Dubos, Proc. Soc. Exptl. Biol. Med., 66, 120, 1947, have since shown that high concentrations of penicillin produce partial lysis of M. tuberculosis and that small inocula of organisms in tween-albumin medium are susceptible to low concentrations of penicillin. No inhibition was obtained with oleic-acid-albumin medium.
PMCID: PMC518479 PMID: 16561490