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Intragastric administration of sweeteners does not affect ghrelin release. WT and α-gust−/− mice were gavaged (a,b) OFS (5.63 g/kg) (n = 8), (c,d) sucralose (8.95 mg/kg) (n = 9) or saline (n = 9–13). Plasma octanoyl and total ghrelin levels were determined 40 min after administration. Results (predicted values ± standard error of the predicted values) are expressed relative to the control stimulation (saline treated WT mice). $ p < 0.05 vs. vehicle treated WT mice.
