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. 2016 Jun 11;7(28):43949–43959. doi: 10.18632/oncotarget.9947

Figure 1. Human pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) express higher level of neural stem cell-associated genes than bone marrow mesenchymal stem cells (BM-MSCs).

Figure 1

(A) Gene expression of Nestin and Musashi in PSC-MSCs (ES-MSCs, iPS-MSCs-1, and iPS-MSCs-2) and BM-MSCs was analyzed by real-time PCR (qPCR). ***p < 0.005; compared to BM-MSCs. (B) Phase-contrast microscopy of BM-MSCs and various PSC-MSCs after being cultured 48 hours in neural differentiation medium (NDM; consist of RA (0.5 μM) in serum-free medium). Arrow indicates dendrite-like processes. (C) Gene expression of Nestin, Musashi, and MAP2 in PSC-MSCs and BM-MSCs after culturing in control complete medium (C) and NDM for 48 hours as analyzed by qPCR. *p < 0.05 and **p < 0.01, compared to Control. Error bars represent ± SEM of three independent experiments. Scale bar: 20 μm.