Table 4. Multivariate analysis for associations of sTILs with DFS, DDFS and OS in TNBCs.
Variables | DFs | DDFs | Os | ||||||
---|---|---|---|---|---|---|---|---|---|
Hr | 95% CI | P-value | Hr | 95% CI | P-value | Hr | 95% CI | P-value | |
sTILs(per10% increase) | 0.95 | 0.93–0.97 | < 0.001* | 0.95 | 0.93–0.97 | < 0.001* | 0.96 | 0.93–0.98 | 0.002* |
sTILs (≤ 20% v > 20%) | |||||||||
sTILs ≤ 20% | 1[Reference] | 0.003* | 1[Reference] | 0.003* | 1[Reference] | 0.02* | |||
sTILs>20% | 0.17 | 0.05–0.53 | 0.12 | 0.03–0.49 | 0.26 | 0.08–0.84 | |||
Age(years) | |||||||||
≤ 50 | 1[Reference] | 0.85 | 1[Reference] | 0.76 | 1[Reference] | 0.64 | |||
> 50 | 1.04 | 0.65–1.70 | 1.09 | 0.65–1.80 | 1.16 | 0.63–2.12 | |||
Tumor size(cm) | |||||||||
pT1 (0.1–2.0) | 1[Reference] | 0.001* | 1[Reference] | 0.001* | 1[Reference] | 0.001* | |||
pT2 (2.1–5.0) | 1.41 | 0.85–2.35 | 1.23 | 0.72-–2.09 | 1.41 | 0.74–2.70 | |||
pT3 (> 5.0) | 6.09 | 2.41–15.39 | 6.20 | 2.42–15.89 | 6.95 | 2.47–19.520 | |||
Nodal status | |||||||||
pN0(0) | 1[Reference] | 0.006* | 1[Reference] | 0.004* | 1[Reference] | 0.02* | |||
pN1(1–3) | 2.44 | 1.10–5.40 | 2.88 | 1.29–6.42 | 2.82 | 1.10–7.28 | |||
pN2/N3(4+) | 2.40 | 1.24–4.66 | 2.41 | 1.20–4.85 | 2.37 | 1.03–5.47 | |||
Tumor grade | |||||||||
2 | 1[Reference] | 0.004* | 1[Reference] | 0.002* | 1[Reference] | 0.01* | |||
3 | 2.33 | 1.30–4.15 | 2.70 | 1.43–5.11 | 2.82 | 1.30–6.08 |
Abbreviations: TNBCs, triple-negative breast cancers; sTILs, stromal tumor-infiltrating lymphocytes; DFS, disease-free survival; DDFS, distant disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.
The P value is significant.