. 2016 Jun 15;7(28):44395–44405. doi: 10.18632/oncotarget.10054

Table 4. Multivariate analysis for associations of sTILs with DFS, DDFS and OS in TNBCs.

Variables	DFs			DDFs			Os
Variables	Hr	95% CI	P-value	Hr	95% CI	P-value	Hr	95% CI	P-value
sTILs(per10% increase)	0.95	0.93–0.97	< 0.001^*	0.95	0.93–0.97	< 0.001^*	0.96	0.93–0.98	0.002^*
sTILs (≤ 20% v > 20%)
sTILs ≤ 20%	1[Reference]		0.003^*	1[Reference]		0.003^*	1[Reference]		0.02^*
sTILs>20%	0.17	0.05–0.53		0.12	0.03–0.49		0.26	0.08–0.84
Age(years)
≤ 50	1[Reference]		0.85	1[Reference]		0.76	1[Reference]		0.64
> 50	1.04	0.65–1.70		1.09	0.65–1.80		1.16	0.63–2.12
Tumor size(cm)
pT1 (0.1–2.0)	1[Reference]		0.001^*	1[Reference]		0.001^*	1[Reference]		0.001^*
pT2 (2.1–5.0)	1.41	0.85–2.35	0.001^*	1.23	0.72-–2.09	0.001^*	1.41	0.74–2.70	0.001^*
pT3 (> 5.0)	6.09	2.41–15.39		6.20	2.42–15.89		6.95	2.47–19.520
Nodal status
pN0(0)	1[Reference]		0.006^*	1[Reference]		0.004^*	1[Reference]		0.02^*
pN1(1–3)	2.44	1.10–5.40	0.006^*	2.88	1.29–6.42	0.004^*	2.82	1.10–7.28	0.02^*
pN2/N3(4+)	2.40	1.24–4.66		2.41	1.20–4.85		2.37	1.03–5.47
Tumor grade
2	1[Reference]		0.004^*	1[Reference]		0.002^*	1[Reference]		0.01^*
3	2.33	1.30–4.15	0.004^*	2.70	1.43–5.11		2.82	1.30–6.08

Abbreviations: TNBCs, triple-negative breast cancers; sTILs, stromal tumor-infiltrating lymphocytes; DFS, disease-free survival; DDFS, distant disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.

The P value is significant.